Document Detail

Ibutilide for treatment of atrial fibrillation in the emergency department.
MedLine Citation:
PMID:  16439743     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to assess the efficacy and safety of ibutilide, a class III antiarrhythmic drug, for acute treatment of atrial fibrillation (AF) in the emergency department (ED) setting. A retrospective analysis was done reviewing all patients with AF who received ibutilide in the ED in a university hospital setting. A total of 22 patients received ibutilide. Another 24 patients who received rate control drugs only served as a control group. Of the 22 patients who received ibutilide, 14 (64%) converted to sinus rhythm. The mean (SD) rate of AF was 137 (24) bpm and the mean QTc interval immediately after conversion to sinus rhythm was 420 (28) ms. There were no complications. In the rate control group 7 patients (29%) converted to sinus rhythm (p<0.05, compared with ibutilide). The mean rate of AF was 126 (26) bpm (p = ns, compared with ibutilide) and the mean QTc interval in those who converted was 377 (28) ms (p<0.05, compared with ibutilide). One patient developed severe bradycardia. Ibutilide is effective for conversion of recent onset AF in patients presenting to the ED and there is a low rate of complications from ibutilide in this setting.
O Viktorsdottir; A Henriksdottir; D O Arnar
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Emergency medicine journal : EMJ     Volume:  23     ISSN:  1472-0213     ISO Abbreviation:  Emerg Med J     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-27     Completed Date:  2006-03-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100963089     Medline TA:  Emerg Med J     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-4     Citation Subset:  IM    
Department of Emergency Medicine, Landspitali University Hospital, Reykjavik, Iceland.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use*
Atrial Fibrillation / drug therapy*
Case-Control Studies
Emergency Service, Hospital
Middle Aged
Retrospective Studies
Sulfonamides / therapeutic use*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Sulfonamides; 130350-52-6/ibutilide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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