Document Detail

Ibutilide in rapid conversion of atrial flutter in octogenarians.
MedLine Citation:
PMID:  12390055     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Atrial flutter is a common sustained atrial tachyarrhythmia for which frequency increases with age. Ibutilide is a novel class III antiarrhythmic agent used for the rapid cardioversion of atrial fibrillation or atrial flutter. AIM: The aim of our study was to assess the use of ibutilide in a selected population of very elderly patients (octogenarians) with recent-onset atrial flutter. METHOD: Twenty-nine consecutive elderly patients (11 male, 18 female; mean age 83 +/- 3 years; interquartile range of 10) with recent-onset atrial flutter were included in the study; none of them had signs or symptoms of severe heart failure, angina or impaired renal or hepatic function. All patients underwent a 10-minute intravenous infusion of ibutilide (0.87 mg in 10 ml). RESULTS: The rate of successful arrhythmia termination was 75.9% within a mean time of 31 +/- 20 minutes. No clinical variables were shown to be associated with successful cardioversion, although there was a tendency towards higher efficacy in patients with a shorter duration of arrhythmia. Two female patients (6.9%) developed torsade de pointes, requiring direct current cardioversion under general anaesthesia. Episodes of nonsustained ventricular tachycardia occurred in two other patients. CONCLUSION: Ibutilide appears to be an effective and well tolerated drug for rapid conversion of recent-onset atrial flutter in octogenarian patients, and may represent a valid approach in the acute management of atrial flutter in this particular set of patients.
Roberto Antonicelli; Paolo Testarmata; Andrea Recanatini
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Drugs & aging     Volume:  19     ISSN:  1170-229X     ISO Abbreviation:  Drugs Aging     Publication Date:  2002  
Date Detail:
Created Date:  2002-10-22     Completed Date:  2003-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102074     Medline TA:  Drugs Aging     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  787-91     Citation Subset:  IM    
Department of Cardiology-CCU, Italian National Centre on Aging (INRCA), Ancona, Italy.
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MeSH Terms
Aged, 80 and over
Anti-Arrhythmia Agents / adverse effects,  therapeutic use*
Atrial Flutter / drug therapy*,  physiopathology
Injections, Intravenous
Middle Aged
Sulfonamides / adverse effects,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Sulfonamides; 130350-52-6/ibutilide

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