| Ibuprofen given pre- and post-operatively for the relief of pain. | |
| | |
MedLine Citation:
|
PMID: 3117914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
155 patients undergoing surgical removal of lower third molars took part in a parallel group, randomised double-blind study to assess the analgesic effect of single pre-operative doses of ibuprofen (400 mg), codeine phosphate (30 mg), a combination of ibuprofen/codeine (400 mg/30 mg), placebo and post-operative single doses of the same combination or diflunisal (250 mg). Patients receiving the combination or ibuprofen pre-operatively took significantly longer between surgery completion and needing the post-operative study treatment than patients receiving codeine phosphate or placebo. At 1 1/2-2 h after post-operative administration, patients receiving the combination post-operatively reported significantly greater decreases in pain severity than those receiving diflunisal. Patients taking the combination post-operatively experienced significantly better pain relief than patients taking diflunisal at 1 and 2 h, but the reverse was true at 5 h. Side-effects reported were mild with no significant differences between the different treatment groups. |
| | |
Authors:
|
C M Hill; M J Carroll; A D Giles; N Pickvance |
Related Documents
:
|
10628594 - Gastrointestinal safety profile of nabumetone: a meta-analysis. 15303784 - Phase iv, open-label assessment of the treatment of actinic keratosis with 3.0% diclofe... 7635724 - Cph and hemicrania continua: requirements of high indomethacin dosages--an ominous sign? 10759624 - Safety and efficacy of nabumetone in osteoarthritis: emphasis on gastrointestinal safety. 12496924 - Low molecular weight heparin and radical prostatectomy: a prospective analysis of safet... 17645604 - Prospective multicenter clinical trial of uretex sup for surgical treatment of stress u... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: International journal of oral and maxillofacial surgery Volume: 16 ISSN: 0901-5027 ISO Abbreviation: Int J Oral Maxillofac Surg Publication Date: 1987 Aug |
Date Detail:
|
Created Date: 1987-12-03 Completed Date: 1987-12-03 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8605826 Medline TA: Int J Oral Maxillofac Surg Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 420-4 Citation Subset: D; IM |
Affiliation:
|
Department of Dental Surgery, School of Dentistry, University of Leeds, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Clinical Trials as Topic Codeine / administration & dosage* Diflunisal / therapeutic use Double-Blind Method Drug Combinations Female Humans Ibuprofen / administration & dosage* Male Middle Aged Molar, Third / surgery Pain, Postoperative / prevention & control* Premedication* Tooth Extraction / adverse effects* |
| Chemical | |
Reg. No./Substance:
|
0/Drug Combinations; 15687-27-1/Ibuprofen; 22494-42-4/Diflunisal; 76-57-3/Codeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thyroglossal cysts in patients over 30 years of age.
Next Document: Observer strategy and the radiographic classification of healing after endodontic surgery.