Document Detail


Ibuprofen Lysinate and Sodium Ibuprofen for Prophylaxis of Patent Ductus Arteriosus in Preterm Neonates.
MedLine Citation:
PMID:  21992864     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This retrospective, non-concurrent cohort study compared the efficacy and safety of Ibuprofen-Lysinate (Arfen, intramuscular formulation, Group I, n=156) used during 2000-2005 and Sodium ibuprofen (Pedea, intravenous solution, Group II, n=60) used during 2006-2008, for the prophylaxis of Patent Ductus Arteriosus in inborn neonates with gestational age ?28 weeks. Ductus closure rate after prophylaxis was significantly higher (73.1% vs 50%; P=0.002) and surgical ligation significantly lower (8.2% vs 23.3%; P=0.005) in Group I. A smaller number of neonates of Group I vs Group II showed oliguria and hemorrhagic disease.
Authors:
Mp De Carolis; I Bersani; G De Rosa; F Cota; C Romagnoli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-15
Journal Detail:
Title:  Indian pediatrics     Volume:  -     ISSN:  0974-7559     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-10-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Neonatology and *Division of Cardiology, Department of Paediatrics, Catholic University of Sacred Heart, Rome, Italy. Correspondence to: De Carolis Maria Pia, Department of Paediatrics, Division of Neonatology, Policlinico A. Gemelli, Catholic University of Sacred Heart, Largo Gemelli 8, 00168, Rome, Italy, mpia.decarolis@rm.unicatt.it.
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