| Ibotenic acid lesions to ventrolateral thalamic nuclei disrupts trace and delay eyeblink conditioning in rabbits. | |
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MedLine Citation:
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PMID: 17335917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intact cerebellar structures (i.e., deep nuclei and perhaps cortex) are essential for acquisition of both simple delay and trace eyeblink (EB) conditioning. However, successful trace conditioning also requires intact cortico-limbic structures (i.e., hippocampus, medial thalamus, and medial prefrontal cortex, mPFC). A direct connection between the cerebellum and ventrolateral thalamic nuclei (VLTN) has been demonstrated in several species. Since VLTN projects to both premotor and prefrontal cortex, it may be an essential link in a cerebellar-thalamic-prefrontal circuit that provides the CNS substrate for acquisition of the trace EB CR. The current studies thus assessed the role of the VLTN on trace EB conditioning in New Zealand albino rabbits. We first verified afferent connections to the mPFC (Brodmann's area 32) from the VLTN, by injecting the retrograde tracer Flourogold(c) into area 32. Strong labeling in VLTN from terminal projections to mPFC were found. We next assessed the role of VLTN in trace eyeblink conditioning in animals that received either sham or ibotenic acid VLTN lesions. EB conditioning began with 10 consecutive daily sessions of trace conditioning, followed immediately by 4 days of extinction, and then 4 days of delay conditioning. VLTN lesions significantly impaired acquisition of both trace and delay conditioning, and impaired extinction. These findings, thus confirm the importance of the VLTN in a postulated cerebellar-thalamic-prefrontal circuit that underlies successful trace, as well as delay EB conditioning. |
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Authors:
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B B Oswald; B Knuckley; S A Maddox; D A Powell |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-01-31 |
Journal Detail:
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Title: Behavioural brain research Volume: 179 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-26 Completed Date: 2007-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 111-7 Citation Subset: IM |
Affiliation:
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Shirley L. Buchanan Neuroscience Laboratory, Dorn VA Medical Center, Columbia, SC 29209, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Association Learning / drug effects, physiology* Conditioning, Classical / drug effects, physiology* Conditioning, Eyelid / drug effects, physiology Female Ibotenic Acid Male Motor Cortex / physiology Motor Skills / drug effects, physiology* Neural Pathways / drug effects, physiology* Prefrontal Cortex / physiology Rabbits Reaction Time / drug effects, physiology Ventral Thalamic Nuclei / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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2552-55-8/Ibotenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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