Document Detail

Ibotenic acid lesions reduce noradrenergic activation in ventromedial hypothalamus during hypoglycemia.
MedLine Citation:
PMID:  16905122     Owner:  NLM     Status:  MEDLINE    
Noradrenergic and GABAergic systems in the ventromedial hypothalamus (VMH) are activated during hypoglycemia and initiate part of the compensatory counterregulatory response. Norepinephrine (NE) terminals innervating the VMH originate in glucosensing hindbrain areas, but whether NE activity in the VMH is under local control or in the hindbrain is unclear. To elucidate the role of neurons intrinsic to the VMH on NE release in the VMH during hypoglycemia, ibotenic acid (IBO), an NMDA receptor agonist that selectively destroys cell bodies, was used. In a 2 x 2 factorial study, IBO (3-5 microg/0.5 microL) or vehicle was stereotaxically administered into the VMH of male Sprague-Dawley rats. One week later, NE concentration in the VMH was measured by microdialysis during insulin-induced hypoglycemia (2.0 U/kg) or euglycemia (saline control). Baseline levels of NE were not statistically different (p=0.10) in IBO-treated compared with vehicle-treated rats (13.3+/-2.8 nM vs. 7.9+/-1.1 nM). The initial increase in interstitial NE concentration during hypoglycemia in control rats was absent in IBO-treated rats (p<0.01). In IBO-treated hypoglycemic rats, NE concentrations increased after 45 min to a similar level observed in control rats during the first 20 min of hypoglycemia. These results are consistent with the suggestion that local neurons in the VMH respond to hypoglycemia and modify NE activation in the VMH during hypoglycemia.
Kelly R Fugo; Marc A Lawson; J Lee Beverly
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-08-14
Journal Detail:
Title:  Brain research     Volume:  1111     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-11     Completed Date:  2006-11-24     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
Neuroscience Program, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.
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MeSH Terms
Autonomic Pathways / metabolism*
Down-Regulation / physiology
Excitatory Amino Acid Agonists / pharmacology
Hypoglycemia / chemically induced,  metabolism*,  physiopathology
Ibotenic Acid / pharmacology
Insulin / pharmacology
Neurons / metabolism*
Neurotoxins / pharmacology
Norepinephrine / metabolism*
Presynaptic Terminals / metabolism,  secretion
Rats, Sprague-Dawley
Rhombencephalon / metabolism,  secretion
Synaptic Transmission / physiology
Time Factors
Ventromedial Hypothalamic Nucleus / metabolism*
Grant Support
Reg. No./Substance:
0/Excitatory Amino Acid Agonists; 0/Neurotoxins; 11061-68-0/Insulin; 2552-55-8/Ibotenic Acid; 51-41-2/Norepinephrine

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