Document Detail

Iatrogenic myocardial edema with potassium cardioplegia.
MedLine Citation:
PMID:  459529     Owner:  NLM     Status:  MEDLINE    
Postischemic myocardial edema depresses left ventricular function and coronary perfusion. Pharmacologic cardioplegia is being used increasingly to enhance myocardial protection during cardiac operations. In the present study we varied the colloid osmotic and osmotic pressures and the infusion pressures of four cardioplegic solutions to determine their respective roles in producing or preventing myocardial edema in a nonischemic setting. We found that myocardial edema during potassium cardioplegia (1) is independent of infusion pressures, (2) is caused by isosmotic crystalloid solutions, (3) is worsened by hyposmolar crystalloid solutions, (4) is avoided by the addition of colloid, and (5) is avoided if the solution is made hyperosmotic with the addition of mannitol.
R P Foglia; D L Steed; D M Follette; E DeLand; G D Buckberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  78     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  AIM; IM    
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MeSH Terms
Body Water / metabolism
Edema, Cardiac / chemically induced*,  physiopathology
Heart Arrest, Induced*
Heart Failure / chemically induced*
Iatrogenic Disease
Myocardial Contraction
Myocardium / metabolism
Osmotic Pressure
Potassium / administration & dosage,  toxicity*
Reg. No./Substance:
0/Solutions; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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