Document Detail


Iatrogenic myelomonocytic leukemia following melphalan treatment of scleromyxedema.
MedLine Citation:
PMID:  3470169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the case of a patient with scleromyxedema with abnormal monoclonal gamma globulin of the kappa type who was treated with melphalan (Alkeran), an alkylating agent. After nine and one-half years of therapy, the patient showed myelomonocytic leukemia. The risk of secondary malignancies must be considered when weighting the benefits and risks of melphalan treatment.
Authors:
F Helm; T N Helm
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cutis     Volume:  39     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-05-12     Completed Date:  1987-05-12     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Diabetes Mellitus, Type 1 / complications
Humans
Leukemia, Myeloid / chemically induced*
Male
Melphalan / adverse effects*
Paraproteinemias / blood,  complications*
Scleroderma, Systemic / complications,  drug therapy,  physiopathology*
Chemical
Reg. No./Substance:
148-82-3/Melphalan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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