| Iatrogenic hyperadrenocorticism and steatohepatitis caused by unapproved medicine. | |
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MedLine Citation:
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PMID: 18591846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 54-year-old man experienced weight gain. He was diagnosed as having hyperglycemia, hypertension and liver damage. Liver biopsy showed steatohepatitis. We initially suspected him as having hyperadrenocorticism. However, both adrenocorticotropic hormone and cortisol levels were low. Later, it was revealed that he took medicine to relieve his gonalgia. His hyperglycemia, hypertension and liver damage improved after he discontinued taking the medicine. An analysis of this medicine showed that it contained desoximetasone, a glucocorticoid compound that had not been approved for medical use in Japan. To adequately diagnose clinical conditions, it is necessary to survey the patient's medicinal history in detail. |
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Authors:
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Akira Kitahara; Kumiko Saga; Shigeki Koide; Tomoaki Isobe; Yutaka Oki; Hirotoshi Nakamura |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-07-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 47 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-07-01 Completed Date: 2008-08-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1231-6 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Kitahara Medical Clinic, Hamamatsu, Japan. kitahara-endo@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocortical Hyperfunction
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chemically induced* Arthralgia / drug therapy Desoximetasone / adverse effects* Drug-Induced Liver Injury / etiology* Fatty Liver / chemically induced* Glucocorticoids / adverse effects* Humans Knee Joint Male Middle Aged Self Medication / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 382-67-2/Desoximetasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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