| Iatrogenic diabetes mellitus during ACTH therapy in an infant with West syndrome. | |
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MedLine Citation:
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PMID: 21253781 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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West syndrome is a rare epileptic disease of infancy, typified by an association of characteristic spasms, hypsarrhythmia on electroencephalography and severe psychomotor retardation or deterioration. Adrenocorticotropic hormone (ACTH) is the current first-line therapy for West syndrome despite the fact that ACTH therapy is associated with various adverse effects. We describe a rare case of iatrogenic diabetes mellitus during ACTH therapy in a patient with symptomatic West syndrome. The infant had cushingoid facies, hirsutism and biochemical evidence of diabetes due to excessive glucocorticoid production with hyperplasia of both adrenal glands at ultrasound examination, without mineralocorticoid excess; in addition, he presented also short-term weight gain, marked electrolyte disturbances, hypokalemic alkalosis and infections. When ACTH is used to treat patients with West syndrome, it is necessary to follow glycemic levels until to the end of therapy. |
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Authors:
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Valeria Calcaterra; Andrea Bottazzi; Chrissoula Tzialla; Stefano D'Arrigo; Daniela Larizza |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-21 |
Journal Detail:
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Title: Acta diabetologica Volume: - ISSN: 1432-5233 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200299 Medline TA: Acta Diabetol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, University of Pavia and IRCCS Policlinico San Matteo Foundation, P.le Golgi n.2, 27100, Pavia, Italy, v.calcaterra@smatteo.pv.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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