Document Detail

Iatrogenic Hyperviscosity and Thrombosis.
MedLine Citation:
PMID:  22915493     Owner:  NLM     Status:  Publisher    
It is well known that hemostatic-thrombotic mechanisms are influenced by hemodynamic factors, such as shear forces affecting platelets or red blood cell aggregation, in turn affecting flow in stenotic regions. Endothelial cell function is also significantly influenced by shear forces acting on the vessel wall. Further, the distribution of shear forces in the vasculature is complex and closely associated with factors determining the flow properties of blood. Therefore, there is a link among alterations in the rheological properties of blood and its elements and the risk for thrombosis, with this linkage confirmed by numerous clinical studies. After discussing relevant rheological and hemodynamic concepts, this review focuses on selected drug-induced conditions that are known to be associated with both hyperviscosity conditions and increased thrombotic risk: oral contraceptives, diuretics, intravenous immunoglobulin, erythropoiesis-stimulating agents, chemotherapy, and radio-contrast media. Alterations of relationships between blood rheology and thrombotic risk related to artificial circulatory environments and physical exercise are also briefly discussed.
Oguz K Baskurt; Herbert J Meiselman
Related Documents :
8074623 - Contribution of cerebrospinal fluid to rheoencephalographic waveforms during hypoxic an...
22730863 - Bloodless extracorporeal membrane oxygenation in the jehovah's witness patient.
17583663 - Bovine blood neutrophil acyloxyacyl hydrolase (aoah) activity during endotoxin and coli...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-22
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  -     ISSN:  1098-9064     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Koc University School of Medicine, Sariyer, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  VEGF-incorporated biomimetic poly(lactide-co-glycolide) sintered microsphere scaffolds for bone tiss...
Next Document:  Synchronization and Complex Dynamics of Oscillators with Delayed Pulse Coupling.