Document Detail

IVF: past and future.
MedLine Citation:
PMID:  12735878     Owner:  NLM     Status:  MEDLINE    
The introduction of IVF into the New World had its roots in Robert Edwards' six-week fellowship at Johns Hopkins in 1965, when he and I made a systematic attempt to fertilize human oocytes in vitro. While fertilization was not claimed in the publication of the work done in 1965, a retrospective examination of published photos indicate that human fertilization was obtained at that time. Edwards and Steptoe achieved a term birth with IVF in 1978, and this stimulated the establishment of an IVF clinic in Norfolk, Virginia. Using ovarian stimulation in 1981, the first delivery in the New World took place. This led to a series of studies on the influence of ovarian stimulation on the normal menstrual cycle and resulted in the finding that with ovarian stimulation there are three response patterns: high, normal and low. It was shown that an LH surge does not occur in ovarian stimulation. This latter observation led to the discovery of the LH surge inhibiting factor. The Norfolk programme became involved in the societal impact of IVF through an invitation to the Vatican, the Ethical Committee of the American Fertility Society (later the American Society for Reproductive Medicine), a lawsuit for libel against the local newspaper, and other activities.
Howard W Jones
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Publication Detail:
Type:  Historical Article; Journal Article; Portraits    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  6     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:    2003 Apr-May
Date Detail:
Created Date:  2003-05-08     Completed Date:  2003-12-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
Eastern Virginia Medical School, Norfolk, Virginia, USA.
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MeSH Terms
Fertilization in Vitro / ethics,  history*,  methods
History, 20th Century
Ovulation Induction / history*,  methods
United States

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