Document Detail

ISYS: a decentralized, component-based approach to the integration of heterogeneous bioinformatics resources.
MedLine Citation:
PMID:  11222265     Owner:  NLM     Status:  MEDLINE    
MOTIVATION: Heterogeneity of databases and software resources continues to hamper the integration of biological information. Top-down solutions are not feasible for the full-scale problem of integration across biological species and data types. Bottom-up solutions so far have not integrated, in a maximally flexible way, dynamic and interactive graphical-user-interface components with data repositories and analysis tools.
RESULTS: We present a component-based approach that relies on a generalized platform for component integration. The platform enables independently-developed components to synchronize their behavior and exchange services, without direct knowledge of one another. An interface-based data model allows the exchange of information with minimal component interdependency. From these interactions an integrated system results, which we call ISYSf1.gif" BORDER="0">. By allowing services to be discovered dynamically based on selected objects, ISYS encourages a kind of exploratory navigation that we believe to be well-suited for applications in genomic research.
A Siepel; A Farmer; A Tolopko; M Zhuang; P Mendes; W Beavis; B Sobral
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioinformatics (Oxford, England)     Volume:  17     ISSN:  1367-4803     ISO Abbreviation:  Bioinformatics     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-10     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9808944     Medline TA:  Bioinformatics     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-94     Citation Subset:  IM    
National Center for Genome Resources, 2935 Rodeo Park Drive East, Santa Fe, NM 87505, USA.
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MeSH Terms
Arabidopsis / genetics
Computational Biology*
Databases, Factual
Genome, Plant
Quantitative Trait, Heritable

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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