Document Detail


ISYS: a decentralized, component-based approach to the integration of heterogeneous bioinformatics resources.
MedLine Citation:
PMID:  11222265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MOTIVATION: Heterogeneity of databases and software resources continues to hamper the integration of biological information. Top-down solutions are not feasible for the full-scale problem of integration across biological species and data types. Bottom-up solutions so far have not integrated, in a maximally flexible way, dynamic and interactive graphical-user-interface components with data repositories and analysis tools.
RESULTS: We present a component-based approach that relies on a generalized platform for component integration. The platform enables independently-developed components to synchronize their behavior and exchange services, without direct knowledge of one another. An interface-based data model allows the exchange of information with minimal component interdependency. From these interactions an integrated system results, which we call ISYSf1.gif" BORDER="0">. By allowing services to be discovered dynamically based on selected objects, ISYS encourages a kind of exploratory navigation that we believe to be well-suited for applications in genomic research.
Authors:
A Siepel; A Farmer; A Tolopko; M Zhuang; P Mendes; W Beavis; B Sobral
Related Documents :
23656945 - Experimental design optimization for electrochemical removal of gentamicin: toxicity ev...
24333395 - Bayesian estimation of erp components from multicondition and multichannel eeg.
24131055 - A peak alignment algorithm with novel improvements in application to electropherogram a...
23568505 - Sparse/dct (s/dct) two-layered representation of prediction residuals for video coding.
18723535 - Predicting acoustic orientation in complex real-world environments.
14727715 - Surface plasmon spectral fingerprinting of adsorbed magnesium phthalocyanine by angle a...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioinformatics (Oxford, England)     Volume:  17     ISSN:  1367-4803     ISO Abbreviation:  Bioinformatics     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-10     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9808944     Medline TA:  Bioinformatics     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-94     Citation Subset:  IM    
Affiliation:
National Center for Genome Resources, 2935 Rodeo Park Drive East, Santa Fe, NM 87505, USA. isys@ncgr.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Arabidopsis / genetics
Computational Biology*
Databases, Factual
Genome, Plant
Quantitative Trait, Heritable
Software*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A Web interface generator for molecular biology programs in Unix.
Next Document:  Transcription-associated protein families are primarily taxon-specific.