Document Detail

ISWI chromatin remodeling in ovarian somatic and germ cells: revenge of the NURFs.
MedLine Citation:
PMID:  17544291     Owner:  NLM     Status:  MEDLINE    
Chromatin has emerged as an important regulator of gene expression, interposed between cell signaling pathways and transcriptional machinery. It participates in transmitting extra- and intra-cellular signals that coordinate ovarian events: ovarian follicle development, the meiotic maturation of the oocyte that precedes ovulation, and the ovulatory process and consequent luteinization. Recent evidence from model organisms and mammals suggests that chromatin signaling is achieved, in part, by imitation switch (ISWI) ATP-dependent chromatin-remodeling complexes. This review highlights a role for complexes containing the ISWI ATPase sucrose nonfermenting-2h (Snf2h) in proliferation in somatic and germ cells and also in meiosis in germ cells. Moreover, complexes containing the Snf2l ATPase dictate the differentiation of somatic cells and act in the induction of the terminal phases of meiosis in the oocyte.
David Pépin; Barbara C Vanderhyden; David J Picketts; Bruce D Murphy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-06-01
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  18     ISSN:  1043-2760     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-29     Completed Date:  2007-08-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-24     Citation Subset:  IM    
Centre for Cancer Therapeutics, Ottawa Health Research Institute, Ottawa, Ontario K1H 8L6, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphatases / physiology*
Cell Proliferation
Chromatin Assembly and Disassembly / physiology*
Meiosis / physiology
Oocytes / physiology*
Ovarian Follicle / cytology,  physiology*
Signal Transduction
Transcription Factors / physiology*
Reg. No./Substance:
0/ISWI protein; 0/Transcription Factors; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chronic lymphocytic leukemia.
Next Document:  Protein kinase C theta (PKCtheta): a key player in T cell life and death.