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IRON-HF study: A randomized trial to assess the effects of iron in heart failure patients with anemia.
MedLine Citation:
PMID:  23680589     Owner:  NLM     Status:  Publisher    
BACKGROUND: Anemia in heart failure patients and has been associated with increased morbi-mortality. Previous studies have treated anemia in heart failure patients with either erythropoietin alone or combination of erythropoietin and intravenous (IV) iron. However, the effect of IV or oral (PO) iron supplementation alone in heart failure patients with anemia was virtually unknown. AIM: To compare, in a double-blind design, the effects of IV iron versus PO iron in anemic heart failure patients. METHODS: IRON-HF study was a multicenter, investigator initiated, randomized, double-blind, placebo controlled trial that enrolled anemic heart failure patients with preserved renal function, low transferrin saturation (TSat) and low-to-moderately elevated ferritin levels. Interventions were Iron Sucrose IV 200mg, once a week, for 5weeks, ferrous sulfate 200mg PO TID, for 8weeks, or placebo. Primary endpoint was variation of peak oxygen consumption (peak VO2) assessed by ergospirometry over 3month follow-up. RESULTS: Eighteen patients had full follow-up data. There was an increment of 3.5ml/kg/min in peak VO2 in the IV iron group. There was no increment in peak VO2 in the PO iron group. Patients' ferritin and TSat increased significantly in both treated groups. Hemoglobin increased similarly in all groups. CONCLUSION: IV iron seems to be superior in improving functional capacity of heart failure patients. However, correction of anemia seems to be at least similar between PO iron and IV iron supplementation.
Luís Beck-da-Silva; Diogo Piardi; Stephan Soder; Luís Eduardo Rohde; Antônio Carlos Pereira-Barretto; Denílson de Albuquerque; Edimar Bocchi; Fábio Vilas-Boas; Lídia Zytynzki Moura; Marcelo W Montera; Salvador Rassi; Nadine Clausell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-13
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Hospital de Clínicas de Porto Alegre, UFRGS, Porto Alegre-RS, Brazil. Electronic address:
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