| IQGAP1: A microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic plasticity. | |
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MedLine Citation:
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PMID: 23018238 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In this article, we review our current understanding of the biology of IQ domain-containing GTPase-Activating Protein 1, IQGAP1, a scaffolding protein with multiple binding partners, which is widely expressed among different cell types, including neurons, and capable of linking Rho-GTPase signaling with cytosleletal elements and environmental cues. Interestingly, a series of recent studies suggest that IQGAP family members have an important role in neuronal development, synaptic plasticity and nervous system disorders involving alterations in spine density. |
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Authors:
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I Jausoro; I Mestres; M Remedi; M Sanchez; A Cáceres |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histology and histopathology Volume: 27 ISSN: 1699-5848 ISO Abbreviation: Histol. Histopathol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
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Languages: eng Pagination: 1385-94 Citation Subset: IM |
Affiliation:
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Laboratory of Neurobiology, Instituto Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET), Córdoba, Argentina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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