| IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton. | |
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MedLine Citation:
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PMID: 21295032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microbial pathogens cause widespread morbidity and mortality. Central to the pathogens' virulence is manipulation of the host cell's cytoskeleton, which facilitates microbial invasion, multiplication, and avoidance of the innate immune response. IQGAP1 is a ubiquitously expressed scaffold protein that integrates diverse signaling cascades. Research has shown that IQGAP1 binds to and modulates the activity of multiple proteins that participate in bacterial invasion. Here, we review data that support a role for IQGAP1 in infectious disease via its ability to regulate the actin cytoskeleton. In addition, we explore other mechanisms by which IQGAP1 may be exploited by microbial pathogens. |
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Authors:
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Hugh Kim; Colin D White; David B Sacks |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-02-02 |
Journal Detail:
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Title: FEBS letters Volume: 585 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-04 Completed Date: 2011-05-03 Revised Date: 2012-03-12 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 723-9 Citation Subset: IM |
Copyright Information:
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Published by Elsevier B.V. |
Affiliation:
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Department of Translational Medicine, Brigham and Women's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism* Animals Cytoskeleton / metabolism* Humans Infection / metabolism*, microbiology*, virology Models, Biological Signal Transduction ras GTPase-Activating Proteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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Z99 CL999999/CL/CLC NIH HHS; //Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/IQ motif containing GTPase activating protein 1; 0/ras GTPase-Activating Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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