Document Detail


The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis.
MedLine Citation:
PMID:  9328465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We searched for novel imprinted genes in a region of human chromosome 11p15.5, which contains several known imprinted genes. Here we describe the cloning and characterization of the IPL ( I mprinted in P lacenta and L iver) gene, which shows tissue-specific expression and functional imprinting, with the maternal allele active and the paternal allele relatively inactive, in many human and mouse tissues. Human IPL is highly expressed in placenta and shows low but detectable expression in fetal and adult liver and lung. Mouse Ipl maps to the region of chromosome 7 which is syntenic with human 11p15.5 and this gene is expressed in placenta and at higher levels in extraembryonic membranes (yolk sac), fetal liver and adult kidney. Mouse and human IPL show sequence similarity to TDAG51 , a gene which was shown to be essential for Fas expression and susceptibility to apoptosis in a T lymphocyte cell line. Like several other imprinted genes, mouse and human IPL genes are small and contain small introns. These data expand the repertoire of known imprinted genes and will be helpful in testing the mechanism of genomic imprinting and the role of imprinted genes in growth regulation.
Authors:
N Qian; D Frank; D O'Keefe; D Dao; L Zhao; L Yuan; Q Wang; M Keating; C Walsh; B Tycko
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human molecular genetics     Volume:  6     ISSN:  0964-6906     ISO Abbreviation:  Hum. Mol. Genet.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-19     Completed Date:  1997-12-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9208958     Medline TA:  Hum Mol Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2021-9     Citation Subset:  IM    
Affiliation:
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF001294;  AF002708
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antigens, CD95 / biosynthesis*,  genetics
Apoptosis / genetics*
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 11 / chemistry*
Cloning, Molecular
Female
Gene Expression
Genomic Imprinting*
Humans
Liver / metabolism*
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Nuclear Proteins*
Organ Specificity / genetics
Placenta / metabolism*
Proteins / genetics*,  metabolism
Sequence Analysis, DNA
Grant Support
ID/Acronym/Agency:
R01CA60765/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD95; 0/Nuclear Proteins; 0/Proteins; 0/TSSC3 protein

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