| IP3 dependent Ca2+ signals in muscle cells are involved in regulation of gene expression. | |
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MedLine Citation:
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PMID: 12415736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Potassium depolarization of cultured muscle cells was employed to study cellular responses linked to calcium signaling. Events occurring after depolarization include i) A transient increase of the IP3 mass (2-10s); ii) A slow calcium transient (5 to 25s) that propagates as a low concentration wave along the myotube showing a distinct calcium transient at the level of cell nuclei. Due to the presence of IP3 receptors both in the SR (A-band region) and in the nuclear envelope, these two events appear to be related; iii) Phosphorylation of mitogen activated kinases (ERK 1/2) and of the transcription factor CREB (30 s-10 min), as well as expression of the early genes c-fos, c-jun and egr-1 mRNA (5-15 min). Several independent pieces of evidence, including results obtained using inhibitors specific for individual steps, allowed us to connect these in a sequential manner. As the same type of signaling cascade can be triggered by oxidants, neurotransmitters and hormones, the ensemble of results allows us to propose a general model to describe signaling events that link membrane stimulation to regulation of gene transcription in skeletal muscle cells. |
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Authors:
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Enrique Jaimovich; María Angélica Carrasco |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological research Volume: 35 ISSN: 0716-9760 ISO Abbreviation: Biol. Res. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-11-05 Completed Date: 2003-02-12 Revised Date: 2007-07-18 |
Medline Journal Info:
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Nlm Unique ID: 9308271 Medline TA: Biol Res Country: Chile |
Other Details:
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Languages: eng Pagination: 195-202 Citation Subset: IM |
Affiliation:
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Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile Casilla 70005, Santiago 6530499, Chile. ejaimovi@machi.med.uchile.cl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Calcium Channels / metabolism, physiology* Calcium Isotopes Calcium Signaling / physiology* Cells, Cultured Cyclic AMP Response Element-Binding Protein / metabolism Gene Expression Regulation* Genes, Immediate-Early* Humans Inositol 1,4,5-Trisphosphate / metabolism* Inositol 1,4,5-Trisphosphate Receptors Muscle, Skeletal / cytology, physiology* Phosphorylation RNA, Messenger / metabolism Receptors, Cytoplasmic and Nuclear / metabolism, physiology* Ryanodine Receptor Calcium Release Channel / physiology Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Calcium Isotopes; 0/Cyclic AMP Response Element-Binding Protein; 0/ITPR1 protein, human; 0/Inositol 1,4,5-Trisphosphate Receptors; 0/RNA, Messenger; 0/Receptors, Cytoplasmic and Nuclear; 0/Ryanodine Receptor Calcium Release Channel; 7440-70-2/Calcium; 85166-31-0/Inositol 1,4,5-Trisphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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