Document Detail


IP-10 can be measured in dried plasma spots in patients with chronic hepatitis C infection.
MedLine Citation:
PMID:  23024806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p<0.0001). The DPS based method for IP-10 detection performs well in HCV-infected patients with either minimal or significant fibrosis.
Authors:
Morten Ruhwald; Ellen Sloth Andersen; Peer Brehm Christensen; Belinda Klemmensen Moessner; Nina Weis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-14
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-15     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45181     Citation Subset:  IM    
Affiliation:
Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark. mruhwald@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
Chemokine CXCL10 / blood*
Dried Blood Spot Testing*
Female
Hepatitis C, Chronic / blood,  complications,  diagnosis*
Humans
Liver Cirrhosis / blood,  diagnosis,  etiology
Male
Middle Aged
ROC Curve
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Chemokine CXCL10
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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