| Intestinal candidiasis: an uncommon cause of necrotizing enterocolitis (NEC) in neonates. | |
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MedLine Citation:
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PMID: 20450270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Candida albicans produces intestinal perforation and necrotizing enterocolitis (NEC) in preterm newborns. We reviewed pathology files in neonates with a diagnosis of NEC (10-year period), gathered history, and reviewed histological materials. Of 249 autopsies, two (0.8%) had systemic candidiasis. From 66 surgical cases with a diagnosis of NEC, five cases (7.5%) had intestinal candidiasis. Candida albicans grew in pre- and post-mortem blood, lung, or peritoneal fluid in all cases. Histologically, the small bowel revealed fungi, sometimes intravascular. Systemic candidiasis with intestinal involvement is an important complication of prematurity and a prevalent cause of sepsis. The presence of intraluminal fungi with associated vascular occlusion may lead to bowel ischemia, necrosis, and perforation. |
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Authors:
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Carlos E Parra-Herran; Liset Pelaez; Juan E Sola; Arnel K Urbiztondo; Maria M Rodriguez |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fetal and pediatric pathology Volume: 29 ISSN: 1551-3823 ISO Abbreviation: Fetal Pediatr Pathol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230972 Medline TA: Fetal Pediatr Pathol Country: England |
Other Details:
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Languages: eng Pagination: 172-80 Citation Subset: IM |
Affiliation:
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Department of Pathology, Division of Pediatric Pathology, University of Miami - Holtz Children's Hospital, Miami, Florida 33136, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Candida albicans
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isolation & purification* Candidiasis / complications*, mortality, surgery Enterocolitis, Necrotizing / etiology*, mortality, surgery Female Gestational Age Humans Infant, Newborn Infant, Premature Intestinal Perforation / microbiology, mortality, pathology, surgery Male Peritonitis / microbiology, mortality, pathology, surgery Retrospective Studies Sepsis / microbiology, pathology Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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