| INH-A21: a donor-selected Staphylococcal human immune globulin for the prevention of late-onset neonatal Staphylococcal infection. | |
MedLine Citation:
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PMID: 16732720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INH-A21 is an experimental human immune globulin for intravenous infusion (IGIV) derived from donors specifically selected for elevated levels of antibodies against the Staphylococcal fibrinogen-binding proteins, serine aspartate dipeptide repeat G and clumping factor A. Phase II results demonstrated that infusions of INH-A21 were well tolerated and there were no trends for increasing adverse events, or the common morbidities associated with prematurity. Enrollment has been completed in (but no results have been released from) a Phase III human trial testing INH-A21 as a prophylactic agent against staphylococcal infection in very low birth weight infants (500-1250 g). |
Authors:
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Barry T Bloom |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on investigational drugs Volume: 15 ISSN: 1744-7658 ISO Abbreviation: Expert Opin Investig Drugs Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-30 Completed Date: 2007-10-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9434197 Medline TA: Expert Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 703-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Kansas University School of Medicine--Wichita, Wesley Medical Centre, 550 North Hillside, Wichita, Kansas 67214, USA. barrybloom@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adhesins, Bacterial
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immunology* Animals Drug Evaluation, Preclinical Humans Immunoglobulins, Intravenous / pharmacokinetics, therapeutic use* Infant, Newborn Infant, Very Low Birth Weight Randomized Controlled Trials as Topic Staphylococcal Infections / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Adhesins, Bacterial; 0/Immunoglobulins, Intravenous; 0/MSCRAMM proteins, Staphylococcus; 0/Veronate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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