Document Detail


INH-A21: a donor-selected Staphylococcal human immune globulin for the prevention of late-onset neonatal Staphylococcal infection.
MedLine Citation:
PMID:  16732720     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INH-A21 is an experimental human immune globulin for intravenous infusion (IGIV) derived from donors specifically selected for elevated levels of antibodies against the Staphylococcal fibrinogen-binding proteins, serine aspartate dipeptide repeat G and clumping factor A. Phase II results demonstrated that infusions of INH-A21 were well tolerated and there were no trends for increasing adverse events, or the common morbidities associated with prematurity. Enrollment has been completed in (but no results have been released from) a Phase III human trial testing INH-A21 as a prophylactic agent against staphylococcal infection in very low birth weight infants (500-1250 g).
Authors:
Barry T Bloom
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  15     ISSN:  1744-7658     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-30     Completed Date:  2007-10-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  703-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Kansas University School of Medicine--Wichita, Wesley Medical Centre, 550 North Hillside, Wichita, Kansas 67214, USA. barrybloom@aol.com
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MeSH Terms
Descriptor/Qualifier:
Adhesins, Bacterial / immunology*
Animals
Drug Evaluation, Preclinical
Humans
Immunoglobulins, Intravenous / pharmacokinetics,  therapeutic use*
Infant, Newborn
Infant, Very Low Birth Weight
Randomized Controlled Trials as Topic
Staphylococcal Infections / prevention & control*
Chemical
Reg. No./Substance:
0/Adhesins, Bacterial; 0/Immunoglobulins, Intravenous; 0/MSCRAMM proteins, Staphylococcus; 0/Veronate

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