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INF-β1b therapy modulates l-arginine and nitric oxide metabolism in patients with relapse remittent multiple sclerosis.
MedLine Citation:
PMID:  23026532     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The scope of this study is the examination of NO(2)+NO(3), 3-nitrotyrosine (3-NT), S-nitrosothiols (RSNO), arginase activity and asymmetric (ADMA) and symmetric (SDMA) dimethyl-l-arginine concentrations in plasma of MS patients during interferon-β1b therapy. METHODS: The study population included 15 (12 women, 3 men) untreated MS patients and 12 (10 women, 2 men) interferon-β1b treated MS patients with clinically definite relapsing MS (McDonalds criteria) for at least 1year and a baseline EDSS score of 1.0 to 3.5 inclusive. Patients were treated with 250μgIU interferon-β1b s.c. every second day during 30months. The disease course was evaluated using correlations between baseline EDSS score and relapse rates in both groups. RESULTS: During interferon-β1b treatment, EDSS scores in treated patients were decreased compared to untreated ones - after 18 and 30months (p<0.05). In interferon-β1b treated MS patients, NO(2)+NO(3), 3-NT and RSNO plasma concentrations were significantly lower (p<0.05), while arginase activity, ADMA and SDMA levels were significantly increased (p<0.05) during the therapy, compared to the baseline levels in treated patients. CONCLUSION: The investigated parameters may be the new biomarkers, providing information for the therapeutic approach and valuable in clinical monitoring.
Authors:
Ivana Stojanovic; Slobodan Vojinovic; Srdjan Ljubisavljevic; Radmila Pavlovic; Jelena Basic; Dusica Pavlovic; Andjelka Ilic; Tatjana Cvetkovic; Maja Stukalov
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  -     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Institute for Biochemistry, Faculty of Medicine, University of Nis, Bul. Dr Zorana Djindjica, 81, 18000 Nis, Serbia. Electronic address: stojanovicivana38@gmail.com.
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