| INF-β1b therapy modulates l-arginine and nitric oxide metabolism in patients with relapse remittent multiple sclerosis. | |
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MedLine Citation:
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PMID: 23026532 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: The scope of this study is the examination of NO(2)+NO(3), 3-nitrotyrosine (3-NT), S-nitrosothiols (RSNO), arginase activity and asymmetric (ADMA) and symmetric (SDMA) dimethyl-l-arginine concentrations in plasma of MS patients during interferon-β1b therapy. METHODS: The study population included 15 (12 women, 3 men) untreated MS patients and 12 (10 women, 2 men) interferon-β1b treated MS patients with clinically definite relapsing MS (McDonalds criteria) for at least 1year and a baseline EDSS score of 1.0 to 3.5 inclusive. Patients were treated with 250μgIU interferon-β1b s.c. every second day during 30months. The disease course was evaluated using correlations between baseline EDSS score and relapse rates in both groups. RESULTS: During interferon-β1b treatment, EDSS scores in treated patients were decreased compared to untreated ones - after 18 and 30months (p<0.05). In interferon-β1b treated MS patients, NO(2)+NO(3), 3-NT and RSNO plasma concentrations were significantly lower (p<0.05), while arginase activity, ADMA and SDMA levels were significantly increased (p<0.05) during the therapy, compared to the baseline levels in treated patients. CONCLUSION: The investigated parameters may be the new biomarkers, providing information for the therapeutic approach and valuable in clinical monitoring. |
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Authors:
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Ivana Stojanovic; Slobodan Vojinovic; Srdjan Ljubisavljevic; Radmila Pavlovic; Jelena Basic; Dusica Pavlovic; Andjelka Ilic; Tatjana Cvetkovic; Maja Stukalov |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-28 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: - ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-10-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Institute for Biochemistry, Faculty of Medicine, University of Nis, Bul. Dr Zorana Djindjica, 81, 18000 Nis, Serbia. Electronic address: stojanovicivana38@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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