Document Detail


IL6 (-174) and TNFA (-308) promoter polymorphisms are associated with systemic creatine kinase response to eccentric exercise.
MedLine Citation:
PMID:  18758806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exertional rhabdomyolysis is a complex and poorly understood entity. The inflammatory system has an important role in muscle injury and repair. Serum creatine kinase (CK) is often used as systemic biomarker representing muscle damage. Considerable variation exists in CK response between different subjects. Genetic elements may act as predisposition factors for exertional rhabdomyolysis. Based on their biological activity, we hypothesized that in healthy subjects IL6 G-174C and TNFA G-308A promoter polymorphisms would be associated with CK response to exercise. We determined serum CK activity pre- and post-maximal eccentric contractions of the elbow flexor muscles. IL6 G-174C and TNFA G-308A genotypes were analyzed for possible relationship with changes in serum CK activity. IL6 G-174C genotype was associated with CK activity in a dose-dependent fashion. Subjects with one or more of the -174C allele had a greater increase and higher peak CK values than subjects homozygous for the G allele (mean +/- SE U/L: GG, 2,604 +/- 821; GC, 7,592 +/- 1,111; CC, 8,403 +/- 3,849, ANOVA P = 0.0003 for GG + GC genotypes versus CC genotype, P = 0.0005 for linear trend). IL6-174CC genotype was associated with a greater than threefold increased risk of massive CK response (adjusted odds ratio 3.29, 95% confidence interval 1.27-7.85, P = 0.009). A milder association (P = 0.06) was noted between TNFA G-308A genotype and CK activity. In conclusion, we found a strong association of the IL6 G-174C genotype with systemic CK response to strenuous exercise. Data suggest that homozygosity for the IL6-174C allele is a clinically important risk factor for exercise-induced muscle injury, further supporting the central role of cytokines in the reactive inflammatory process of muscle damage and repair.
Authors:
Chen Yamin; José Alberto Ramos Duarte; José Manuel Fernandes Oliveira; Offer Amir; Moran Sagiv; Nir Eynon; Michael Sagiv; Ruthie E Amir
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Publication Detail:
Type:  Journal Article     Date:  2008-08-30
Journal Detail:
Title:  European journal of applied physiology     Volume:  104     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2008-11-13     Revised Date:  2009-05-01    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  579-86     Citation Subset:  IM    
Affiliation:
Department of Genetics and Molecular Biology, Zinman College of Physical Education and Sport Sciences at the Wingate Institute, 42902 Netanya, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Creatine Kinase / blood*
Elbow
Exercise*
Female
Gene Frequency
Genetic Predisposition to Disease
Homozygote
Humans
Interleukin-6 / genetics*
Male
Muscle Contraction / genetics*
Muscle, Skeletal / enzymology,  immunology,  physiopathology*
Odds Ratio
Polymorphism, Genetic*
Promoter Regions, Genetic*
Rhabdomyolysis / enzymology,  genetics*,  immunology,  physiopathology
Risk Assessment
Risk Factors
Tumor Necrosis Factor-alpha / genetics*
Chemical
Reg. No./Substance:
0/IL6 protein, human; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; EC 2.7.3.2/Creatine Kinase
Comments/Corrections
Comment In:
Eur J Appl Physiol. 2009 May;106(2):315   [PMID:  19352693 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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