| IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 21889215 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n=281) and non-responders (n=307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients. |
| | |
Authors:
|
S Malhotra; C Morcillo-Suárez; D Brassat; R Goertsches; J Lechner-Scott; E Urcelay; O Fernández; J Drulovic; A García-Merino; F Martinelli Boneschi; A Chan; K Vandenbroeck; A Navarro; M F Bustamante; J Río; D A Akkad; G Giacalone; A J Sánchez; L Leyva; R Alvarez-Lafuente; U K Zettl; J Oksenberg; X Montalban; M Comabella |
Related Documents
:
|
909025 - Miconazole in the treatment of chronic mucocutaneous candidiasis: a preliminary report. 3341805 - No apparent neurologic defect in a patient with xeroderma pigmentosum complementation g... 22030425 - Tgf-beta 1 codon 10 polymorphism is associated with cerebral svd. 10949725 - Antiphospholipid antibodies in leprotic patients: a correlation with disease manifestat... 10452775 - Ige reactivity to api g 1, a major celery allergen, in a central european population is... 12081735 - New insight into bile flow dynamics in anomalous arrangement of the pancreaticobiliary ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-31 |
Journal Detail:
|
Title: Journal of neuroimmunology Volume: - ISSN: 1872-8421 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-9-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
|
Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management.
Next Document: Predicting complications after adenotonsillectomy in children 3 years old and younger.