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IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis.
MedLine Citation:
PMID:  21889215     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n=281) and non-responders (n=307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients.
Authors:
S Malhotra; C Morcillo-Suárez; D Brassat; R Goertsches; J Lechner-Scott; E Urcelay; O Fernández; J Drulovic; A García-Merino; F Martinelli Boneschi; A Chan; K Vandenbroeck; A Navarro; M F Bustamante; J Río; D A Akkad; G Giacalone; A J Sánchez; L Leyva; R Alvarez-Lafuente; U K Zettl; J Oksenberg; X Montalban; M Comabella
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-31
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  -     ISSN:  1872-8421     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain.
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