| IL28B and PNPLA3 Polymorphisms Affect Histological Liver Damage in Patients with Non-alcoholic Fatty Liver Disease. | |
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MedLine Citation:
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PMID: 22314430 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Genetic background may affect liver damage in patients with non-alcoholic fatty liver disease (NAFLD). The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibrosis, in NAFLD patients. METHODS: One hundred sixty consecutive NAFLD patients, were assessed by liver biopsy (Kleiner score); anthropometric, and biochemical and metabolic features were included. IL28B rs12979860 C>T, IL28B rs8099917 G>C, and PNPLA3 rs738409 C>G single nucleotide polymorphisms were tested. RESULTS: Seventy-four(46.2%) patients had IL28B rs 12979860 CC polymorphism, compared with 72(45%) and 14(8.8%)with TC and TT variants, respectively. PNPLA3 rs738409 CC polymorphism was present in 47(29.4%) patients, compared with 79(49.4%) and 34(21.3%) with CG and GG variants, respectively. Multivariate logistic regression analysis showed that age (OR 1.043, 95% CI 1.012-1.075, p= 0.007), triglycerides (OR 1.005, 95% CI 1.000-1.010, p= 0.04), hyperuricemia (OR 5.027, 95% CI 1.839-13.742, p= 0.002), IL28B rs 12979860 TT/TC (OR 0.219, 95% CI 0.101-0.472, p< 0.001), and steatosis grade (OR 1.704, 95% CI 1.048-2.773, p= 0.03) were independently linked to moderate-severe lobular inflammation. Finally, IL28B rs 12979860 CC was associated with severe fibrosis (F3-F4) on univariate analysis, even if only older age (OR 1.064, 95% CI 1.026-1.104, p=0.001), high HOMA (OR 1.213, 95% CI 1.068-1.377, p=0.003), and lobular inflammation (OR 3.181, 95%CI 1.438-7.036, p=0.004), remained associated on multivariate logistic regression analysis. CONCLUSIONS: In NAFLD patients, IL28B rs 12979860 CC genotype, together with PNPLA3 rs738409 GG, is associated with the severity of liver damage. |
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Authors:
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Salvatore Petta; Stefania Grimaudo; Calogero Cammà; Daniela Cabibi; Vito Di Marco; Giusalba Licata; Rosaria Maria Pipitone; Antonio Craxì |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-4 |
Journal Detail:
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Title: Journal of hepatology Volume: - ISSN: 0168-8278 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy; Cattedra di Anatomia Patologica, University of Palermo, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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