Document Detail

IL-9(+) IL-10(+) T cells link immediate allergic response to late phase reaction.
MedLine Citation:
PMID:  21488868     Owner:  NLM     Status:  MEDLINE    
The mechanism underlying late-phase allergic reactions (LPR) remains incompletely understood. This study aimed to investigate the role of a newly described subset of T cells, interleukin (IL)-9(+) IL-10(+) T cells, in the pathogenesis of LPR. Using a T helper type 2 (Th2) inflammatory mouse model, we examined the frequency of IL-9(+) IL-10(+) T cells in the jejunum by immunohistochemistry. The LPR in the jejunum was observed afterwards. The cytokine profile of IL-9(+) IL-10(+) T cells was characterized and the major cytokine that plays the critical role in the initiation of LPR was investigated. Abundant IL-9(+) IL-10(+) T cells as well as inflammatory cell extravasation in the jejunal sections were observed in sensitized mice 48 h after specific antigen challenge. IL-9(+) IL-10(+) T cells expressed high levels of macrophage inflammatory protein 1 (MIP1) that could be enhanced by T cell receptor activation. MIP1 facilitated macrophage extravasation in local tissue. Macrophage-derived MIP2 contributed to neutrophil infiltration in the intestine in LPR. Pretreatment with anti-MIP antibody inhibited the LPR in the intestine. IL-9(+) IL-10(+) T cells play an important role in LPR. This subset of T cells has the potential to be a novel therapeutic target in the treatment of LPR and LPR-related inflammation.
S-H He; Z-Q Liu; X Chen; C-H Song; L-F Zhou; W-J Ma; L Cheng; Y Du; S-G Tang; P-C Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-13
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  165     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-03     Completed Date:  2011-08-29     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-37     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors; Clinical and Experimental Immunology © 2011 British Society for Immunology.
Clinical Experimenmtal Center, The First Affiliated Hospital, Nanjing Medical University, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada.
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MeSH Terms
Antibodies, Blocking / administration & dosage
Cell Movement / drug effects
Cells, Cultured
Chemokine CCL3 / immunology,  metabolism*
Disease Models, Animal
Hypersensitivity, Delayed / immunology*
Interleukin-10 / biosynthesis
Interleukin-9 / biosynthesis
Jejunum / pathology
Macrophages / drug effects,  immunology,  metabolism*,  pathology
Neutrophils / drug effects,  immunology,  metabolism*,  pathology
T-Lymphocytes / immunology,  metabolism*,  pathology
Grant Support
191063//Canadian Institutes of Health Research; 220058//Canadian Institutes of Health Research
Reg. No./Substance:
0/Antibodies, Blocking; 0/Chemokine CCL3; 0/Interleukin-9; 130068-27-8/Interleukin-10

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