Document Detail

IL-6 polymorphism associated with fatal outcome in patients with severe traumatic brain injury.
MedLine Citation:
PMID:  21314275     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to test whether a functional polymorphism (-174C/G) located in the promoter region of the interleukin-6 (IL-6) gene is associated with primary short-term outcome (death or Intensive Care Unit discharge) in patients with severe traumatic brain injury (TBI).
METHODS: The study group consisted of 77 male patients who suffered severe TBI. The -174C/G IL-6 polymorphism was analysed by polymerase chain reaction (PCR) followed by restriction digestion.
RESULTS: Severe TBI was associated with a 44% mortality rate. The GG genotype was significantly more frequent in the survivor group than in non-surviving patients (67% vs 41%; p =?0.038); similarly, the IL-6 -174G allele was more frequent in the survivor group than in non-surviving patients (81% vs 65%; p =0.031).
CONCLUSION: The findings indicate that genetic variation regarding inflammatory response has significant impact on the short-term outcome for patients after acute severe TBI.
André Luiz Dalla Libera; Andrea Regner; Juliana de Paoli; Leonara Centenaro; Tatiane Tolazzi Martins; Daniel Simon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-11
Journal Detail:
Title:  Brain injury     Volume:  25     ISSN:  1362-301X     ISO Abbreviation:  Brain Inj     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-08-29     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  8710358     Medline TA:  Brain Inj     Country:  England    
Other Details:
Languages:  eng     Pagination:  365-9     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Brain Injuries / genetics*,  mortality
Child, Preschool
Glasgow Outcome Scale
Injury Severity Score
Interleukin-6 / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic
Promoter Regions, Genetic / genetics*
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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