| IL-6 polymorphism associated with fatal outcome in patients with severe traumatic brain injury. | |
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MedLine Citation:
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PMID: 21314275 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: The aim of this study was to test whether a functional polymorphism (-174C/G) located in the promoter region of the interleukin-6 (IL-6) gene is associated with primary short-term outcome (death or Intensive Care Unit discharge) in patients with severe traumatic brain injury (TBI). Methods: The study group consisted of 77 male patients who suffered severe TBI. The -174C/G IL-6 polymorphism was analysed by polymerase chain reaction (PCR) followed by restriction digestion. Results: Severe TBI was associated with a 44% mortality rate. The GG genotype was significantly more frequent in the survivor group than in non-surviving patients (67% vs 41%; p = 0.038); similarly, the IL-6 -174G allele was more frequent in the survivor group than in non-surviving patients (81% vs 65%; p = 0.031). Conclusion: The findings indicate that genetic variation regarding inflammatory response has significant impact on the short-term outcome for patients after acute severe TBI. |
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Authors:
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André Luiz Dalla Libera; Andrea Regner; Juliana de Paoli; Leonara Centenaro; Tatiane Tolazzi Martins; Daniel Simon |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-11 |
Journal Detail:
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Title: Brain injury : [BI] Volume: - ISSN: 1362-301X ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710358 Medline TA: Brain Inj Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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