| IL-6 modifies mRNA expression in mouse. | |
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MedLine Citation:
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PMID: 21352507 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: The aim of the present study was to test the hypothesis that interleukin-6 plays a role in exercise-induced PGC-1α and TNFα mRNA responses in skeletal muscle and to examine the potential IL-6 mediated AMPK regulation in these responses. Methods: Whole body IL-6 knockout and wildtype (WT) male mice (4 month) performed 1h treadmill exercise. White gastrocnemius (WG) and quadriceps muscles were removed immediately (0') or 4h after exercise and from mice not run acutely. Results: Acute exercise reduced only in WT muscle glycogen concentration to 55% and 35% (P<0.05) of resting level in Quad and WG, respectively. While AMPK and ACC phosphorylation increased 1.3 fold (P<0.05) in WG and 2 fold in Quad immediately after exercise in WT mice, no change was detected in WG in IL-6 KO mice. The PGC-1α mRNA content was in resting WG 1.8 fold higher (P<0.05) in WT mice than in IL-6 KO mice. Exercise induced a delayed PGC-1α mRNA increase in Quad in IL-6 KO mice (12 fold at 4h) relative to WT mice (5 fold at 0'). The TNFα mRNA content was in resting Quad 2 fold higher (P<0.05) in IL-6 KO than in WT, and WG TNFα mRNA increased 2 fold (P<0.05) immediately after exercise only in IL-6 KO. Conclusion: In conclusion, IL-6 affects exercise-induced glycogen use, AMPK signalling and TNFα mRNA responses in mouse skeletal muscle. |
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Authors:
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H Adser; Jfp Wojtaszewski; J Hidalgo; Ah Jakobsen; K Kiilerich; H Pilegaard |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-26 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: - ISSN: 1748-1716 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Journal compilation © 2011 Scandinavian Physiological Society. |
Affiliation:
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Centre of Inflammation and Metabolism Copenhagen Muscle Research Centre August Krogh Building, Department of Biology, University of Copenhagen, Denmark JUAN Department of Sport Sciences, University of Copenhagen, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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