Document Detail


IL-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats.
MedLine Citation:
PMID:  19907006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent gene array and molecular studies have suggested that an abnormal gene expression profile of interleukin-6 (IL-6) in the nucleus tractus solitarii (NTS), a pivotal region for regulating arterial pressure, may be related to the development of neurogenic hypertension. However, the precise functional role of IL-6 in the NTS remains unknown. In the present study, we have tested whether IL-6 affects cardiovascular control at the level of the NTS. IL-6 (1, 10, and 100 fmol) was microinjected in the NTS of Wistar rats (280-350 g) under urethane anesthesia. Although the baseline levels of arterial pressure and heart rate did not change following IL-6 injections, the cardiac baroreflex in response to increased arterial pressure was dose-dependently attenuated. In addition, IL-6 (100 fmol) microinjections also attenuated l-glutamate-induced bradycardia at the level of the NTS. Immunohistochemical detection of IL-6 in naïve rats demonstrated that it was predominantly observed in neurons within the brain stem, including the NTS. These findings suggest that IL-6 within the NTS may play an important role for regulating cardiovascular control via modulation of input signals from baroreceptor afferents. Whether the abnormal gene expression of IL-6 in the NTS is associated in a causal way with hypertension remains to be resolved.
Authors:
Miwa Takagishi; Hidefumi Waki; Mohammad E R Bhuiyan; Sabine S Gouraud; Akira Kohsaka; He Cui; Toshiya Yamazaki; Julian F R Paton; Masanobu Maeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-11
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  298     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-01-11     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R183-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Baroreflex / drug effects*,  physiology
Blood Pressure / drug effects,  physiology
Dose-Response Relationship, Drug
Heart / physiology*
Heart Rate / drug effects,  physiology
Interleukin-6 / administration & dosage,  metabolism,  pharmacology*
Male
Microinjections
Models, Animal
Rats
Rats, Wistar
Solitary Nucleus / drug effects*,  metabolism
Grant Support
ID/Acronym/Agency:
RG/07/006/23634//British Heart Foundation
Chemical
Reg. No./Substance:
0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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