| IL-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats. | |
| | |
MedLine Citation:
|
PMID: 19907006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent gene array and molecular studies have suggested that an abnormal gene expression profile of interleukin-6 (IL-6) in the nucleus tractus solitarii (NTS), a pivotal region for regulating arterial pressure, may be related to the development of neurogenic hypertension. However, the precise functional role of IL-6 in the NTS remains unknown. In the present study, we have tested whether IL-6 affects cardiovascular control at the level of the NTS. IL-6 (1, 10, and 100 fmol) was microinjected in the NTS of Wistar rats (280-350 g) under urethane anesthesia. Although the baseline levels of arterial pressure and heart rate did not change following IL-6 injections, the cardiac baroreflex in response to increased arterial pressure was dose-dependently attenuated. In addition, IL-6 (100 fmol) microinjections also attenuated l-glutamate-induced bradycardia at the level of the NTS. Immunohistochemical detection of IL-6 in naïve rats demonstrated that it was predominantly observed in neurons within the brain stem, including the NTS. These findings suggest that IL-6 within the NTS may play an important role for regulating cardiovascular control via modulation of input signals from baroreceptor afferents. Whether the abnormal gene expression of IL-6 in the NTS is associated in a causal way with hypertension remains to be resolved. |
| | |
Authors:
|
Miwa Takagishi; Hidefumi Waki; Mohammad E R Bhuiyan; Sabine S Gouraud; Akira Kohsaka; He Cui; Toshiya Yamazaki; Julian F R Paton; Masanobu Maeda |
Related Documents
:
|
22463196 - Nonlinear wall pressure of a plunged granular column. 754496 - The role of "the law of initial value" and the levels of the central nervous system in ... 23382406 - Prognostic significance of baseline heart rate and its interaction with beta-blocker us... 18851926 - Sympathetic activation in congestive heart failure: reproducibility of neuroadrenergic ... 3923076 - Regional coronary hemodynamic responses during the cold pressor test: lack of effect of... 8068576 - Abnormalities of autonomic nervous control in human hypertension. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-11 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 298 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-24 Completed Date: 2010-01-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R183-90 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Wakayama Medical University School of Medicine, Wakayama, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Baroreflex / drug effects*, physiology Blood Pressure / drug effects, physiology Dose-Response Relationship, Drug Heart / physiology* Heart Rate / drug effects, physiology Interleukin-6 / administration & dosage, metabolism, pharmacology* Male Microinjections Models, Animal Rats Rats, Wistar Solitary Nucleus / drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Calcineurin activates interleukin-6 transcription in mouse skeletal muscle in vivo and in C2C12 myot...
Next Document: Radiation-induced reductions in transporter mRNA levels parallel reductions in intestinal sugar tran...