Document Detail


IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions.
MedLine Citation:
PMID:  18573547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin-6 (IL-6), a proinflammatory cytokine, is well known as a mediator in early stage inflammatory immune reactions. In recent years, accumulating evidence has shown that IL-6 is concomitant with the occurrence of major depression. However, the identification of the role of IL-6, as either an illness causation or immunotherapy in depression, remains to be further established. In the present study, 5-week old male Sprague-Dawley (SD) rats were used along with the forced swim test (FST) and pharmacological techniques. The data show that rats subjected to 3-day intra-amygdala or intra-hippocampus, but not intra-frontal cortex, IL-6 treatments manifested a significant increase in the immobility time (IMT) in the FST. In addition, there was no obvious difference in body temperature between normal and 3-day IL-6 treated rats. Conversely, the rats receiving 3-day intra-amygdala or intra-hippocampus IL-6 inhibitor treatment expressed a significant reduction in IMT in the FST. Moreover, the 3-day IL-6 treated rats treated with SL 327, a blood-brain barrier penetrating MEK inhibitor, prior to the FST showed a significant decrease in the IL-6 elevated IMT. In addition, the results in the Western blot analysis were in parallel with those in the behavioral tests. Taken together, the results show that the immobile behavior of rats in the FST could be modulated by IL-6 via the amygdala or the hippocampus. Furthermore, the Erk1/2 activation in the amygdala or hippocampus seemed to play a role in the IL-6 mediated immobile behavioural alterations of rats in the FST.
Authors:
Tung-Huan Wu; Chih-Hung Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-20
Journal Detail:
Title:  Behavioural brain research     Volume:  193     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-11-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  183-91     Citation Subset:  IM    
Affiliation:
The Graduate Institute of Biological Science and Technology, Chung Hwa University of Medical Technology, Tainan County, Taiwan 717, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Aminoacetonitrile / administration & dosage,  analogs & derivatives,  pharmacology
Amygdala / drug effects*,  metabolism,  physiology
Animals
Behavior, Animal / drug effects*,  physiology
Blotting, Western
Body Temperature / drug effects
Enzyme Activation / drug effects
Hippocampus / drug effects*,  metabolism,  physiology
Immobility Response, Tonic / drug effects,  physiology
Interleukin-6 / administration & dosage,  metabolism,  pharmacology*
Male
Microinjections
Mitogen-Activated Protein Kinase 1 / metabolism*
Mitogen-Activated Protein Kinase 3 / metabolism*
Motor Activity / drug effects,  physiology
Rats
Rats, Sprague-Dawley
Stress, Psychological / metabolism,  physiopathology
Sulfoxides / administration & dosage,  pharmacology
Swimming / physiology
Tetrazoles / administration & dosage,  pharmacology
Chemical
Reg. No./Substance:
0/Interleukin-6; 0/Ro 106-9920; 0/SL 327; 0/Sulfoxides; 0/Tetrazoles; 540-61-4/Aminoacetonitrile; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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