| IL-6 is an intermediate in IL-1-induced thymocyte proliferation. | |
| | |
MedLine Citation:
|
PMID: 2786028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Both IL-1 and IL-6 have been shown to be comitogenic for lectin-stimulated thymocytes. Thymocytes cultured in the presence of IL-1 produce IL-6 themselves. This IL-6 production is caused by a cell population with low buoyant density. After removal of these cells, IL-6 or IL-2 are still co-mitogenic for thymocytes whereas IL-1 is not. Addition of IL-1 to such thymocytes renders them about 100-fold more sensitive to IL-6. At all conditions proliferation is inhibitable with antibodies to IL-2 and to the IL-2R. Our experiments show that IL-1-driven proliferation of thymocytes is dependent on endogenous IL-6 production and that in the classical thymocyte assay IL-1 has a dual role: it induces IL-6 production and it greatly increases the sensitivity for IL-6. |
| | |
Authors:
|
M Helle; L Boeije; L A Aarden |
Related Documents
:
|
2465548 - Regulation of interleukin 1 and its receptor in human keratinocytes. 8514888 - Interleukin-6 production in posttransplant lymphoproliferative disease. 2618588 - Search for a retrovirus in long-term cultured cerebrospinal fluid cells and peripheral ... 3269358 - Thymic stroma-derived t cell growth factor: its role in the growth of immature thymocyt... 20650228 - Interspecies differences in glutathione-dependent detoxication of hydroperoxides in sho... 17199578 - Effects of psoralen plus ultraviolet a irradiation on cultured epidermal cells in vitro... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 142 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1989 Jun |
Date Detail:
|
Created Date: 1989-07-06 Completed Date: 1989-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 4335-8 Citation Subset: AIM; IM |
Affiliation:
|
Central Laboratory, Netherlands Red Cross Blood Transfusion Service, Amsterdam. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adjuvants, Immunologic
/
pharmacology Animals Cell Separation Centrifugation, Density Gradient Drug Synergism Interleukin-1 / pharmacology* Interleukin-2 / physiology Interleukin-6 Interleukins / biosynthesis, pharmacology, physiology* Leukocyte Count Lymphocyte Activation* / drug effects Mice Mice, Inbred C3H T-Lymphocytes / immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Adjuvants, Immunologic; 0/Interleukin-1; 0/Interleukin-2; 0/Interleukin-6; 0/Interleukins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of the growth rate of mouse fibroblasts by IL-3-activated mouse bone marrow-derived mast ...
Next Document: Regulation of the expression of IL-6 in human monocytes.