Document Detail

IL-6 is an intermediate in IL-1-induced thymocyte proliferation.
MedLine Citation:
PMID:  2786028     Owner:  NLM     Status:  MEDLINE    
Both IL-1 and IL-6 have been shown to be comitogenic for lectin-stimulated thymocytes. Thymocytes cultured in the presence of IL-1 produce IL-6 themselves. This IL-6 production is caused by a cell population with low buoyant density. After removal of these cells, IL-6 or IL-2 are still co-mitogenic for thymocytes whereas IL-1 is not. Addition of IL-1 to such thymocytes renders them about 100-fold more sensitive to IL-6. At all conditions proliferation is inhibitable with antibodies to IL-2 and to the IL-2R. Our experiments show that IL-1-driven proliferation of thymocytes is dependent on endogenous IL-6 production and that in the classical thymocyte assay IL-1 has a dual role: it induces IL-6 production and it greatly increases the sensitivity for IL-6.
M Helle; L Boeije; L A Aarden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  142     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-06     Completed Date:  1989-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4335-8     Citation Subset:  AIM; IM    
Central Laboratory, Netherlands Red Cross Blood Transfusion Service, Amsterdam.
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MeSH Terms
Adjuvants, Immunologic / pharmacology
Cell Separation
Centrifugation, Density Gradient
Drug Synergism
Interleukin-1 / pharmacology*
Interleukin-2 / physiology
Interleukins / biosynthesis,  pharmacology,  physiology*
Leukocyte Count
Lymphocyte Activation* / drug effects
Mice, Inbred C3H
T-Lymphocytes / immunology*,  metabolism
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Interleukin-1; 0/Interleukin-2; 0/Interleukin-6; 0/Interleukins

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