Document Detail


IL-6 and TNFalpha across the umbilical circulation in term pregnancies: relationship with labour events.
MedLine Citation:
PMID:  20171025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We have determined venous and arterial cord blood levels for IL-6 and TNFalpha at the time of delivery to assess gestational tissue versus fetal sources in labouring and non-labouring patients at term, and the relationship to labour events. METHODS: Fifty-five patients were studied (elective cesarean section n=24, and labouring n=31) with blood sampling from a clamped segment of cord after delivery of the fetus and from the cord at its insertion into the placenta after delivery of the placenta, with subsequent measurement of blood gases, pH, IL-6 and TNFalpha. RESULTS: Umbilical cord levels for IL-6 were increased by 4 fold in low risk labouring patients, and a further 6 fold when showing histologic chorioamnionitis, but with no evident effect of nuchal cord with 'variable' fetal heart rate decelerations, fetal acidemia, nor of labour duration. IL-6 levels from the cord at its insertion into the placenta were generally higher than those from the respective umbilical levels indicating that placental release of IL-6 into cord blood must be occurring. However, a consistent venoarterial difference for IL-6 and thereby a net flux from the placenta could not be demonstrated. TNFalpha levels for both patient groups were uniformly low for all of the cord measurements with no significant differences noted. CONCLUSION: Umbilical cord levels for IL-6 are increased in low risk labouring patients at term in the absence of evident infection which likely involves both gestational tissue and fetal contributions. Cord levels for IL-6 are further increased in low risk labouring patients showing histologic chorioamnionitis which might then contribute to newborn morbidity in these pregnancies.
Authors:
Greg Duncombe; Ruud A W Veldhuizen; Robert J Gratton; Victor K M Han; Bryan S Richardson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-18
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-09     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Children Health Research Institute, University of Western Ontario, London, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Cesarean Section
Chorioamnionitis / blood,  diagnosis
Female
Fetal Blood / metabolism*
Gestational Age
Humans
Interleukin-6 / blood*
Labor Onset / blood*
Nuchal Cord / blood
Organ Size
Placenta / blood supply,  metabolism*
Pregnancy
Term Birth / blood*
Tumor Necrosis Factor-alpha / blood*
Chemical
Reg. No./Substance:
0/IL6 protein, human; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

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