Document Detail

IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis.
MedLine Citation:
PMID:  21503403     Owner:  NLM     Status:  MEDLINE    
Cytokines are molecules that act as mediators of immune response; cerebral spinal fluid (CSF) IL-6 is found in all meningeal inflammatory diseases, but IL-8 is associated with acute bacterial meningitis (ABM). A case control study was done to ascertain the discriminatory power of these cytokines in differentiating ABM from aseptic meningitis (AM); IL-6 and IL-8 CSF concentrations were tested through ELISA in samples collected from patients who underwent investigation for meningitis. Sixty patients, 18 with AM, nine with bacteriologic confirmed ABM and 33 controls, assisted in 2005 (MA and controls) and 2007 (ABM) were included. Differently from controls, IL-6 concentrations were increased both in MA and ABM patients (p < 0.05). CSF IL-8 levels were higher in ABM than in AM and controls (p < 0.05). Discriminatory power in ABM as assessed by the area under receiver operator (ROC) curve was 0.951 for IL-8, using a cut-off of 1.685 ng/dL (100% of sensitivity and 94% of specificity). The CSF concentration of both IL-6 and IL-8 are increased in the presence of meningeal inflammation, IL-8 could be an important tool to differentiate ABM from AM.
Vitor Laerte Laerte Pinto Junior; Maria Cristina Rebelo; Rachel Novaes Gomes; Edson Fernandes de Assis; Hugo C Castro-Faria-Neto; Marcio Neves Bóia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  15     ISSN:  1678-4391     ISO Abbreviation:  Braz J Infect Dis     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-09-30     Revised Date:  2011-10-03    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  156-8     Citation Subset:  IM    
Oswaldo Cruz Foundation, Brasilia, DF, Brazil.
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MeSH Terms
Biological Markers / cerebrospinal fluid
Case-Control Studies
Child, Preschool
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Infant, Newborn
Interleukin-6 / cerebrospinal fluid*
Interleukin-8 / cerebrospinal fluid*
Meningitis, Aseptic / cerebrospinal fluid,  diagnosis*
Meningitis, Bacterial / cerebrospinal fluid,  diagnosis*
Middle Aged
Sensitivity and Specificity
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Interleukin-8

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