| IL-6, IL-8 and IL-10 levels in healthy weight and overweight children. | |
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MedLine Citation:
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PMID: 20190550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIM: In adults, studies have shown that obesity is a chronic low-grade inflammatory state characterized by altered levels of cytokines. Studies in children have mainly focused on C-reactive protein and adiponectin, and there is limited data for other inflammatory markers in healthy weight and overweight children. The aim of this study was to measure IL-6, IL-8 and IL-10 levels in healthy normal weight and overweight children at 8 and 15 years. METHODS: 118 normal weight and overweight children (59 boys) from the Nepean longitudinal study were recruited at age 8 years and followed up at 15 years. Serum IL-6, IL-8 and IL-10 levels were measured at both time-points. RESULTS: At 8 years, we found no significant differences in cytokine levels between normal weight and overweight (owt)/obese (ob) groups. However, at 15 years, owt/ob girls (n = 23) had higher levels of IL-6 (p = 0.04), IL-8 (p = 0.04) and IL-10 (p = 0.03) compared to normal weight girls (n = 36), even after adjustment for puberty; no differences were seen in boys. CONCLUSION:The effects of obesity on IL-6, IL-8 and IL-10 levels vary with age and sex, with owt/ob girls at 15 years showing raised IL-6, IL-8 and IL-10 levels compared to healthy weight girls. |
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Authors:
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Charmaine S Tam; Sarah P Garnett; Christopher T Cowell; Leonie K Heilbronn; Jennifer W Lee; Melanie Wong; Louise A Baur |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-09 |
Journal Detail:
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Title: Hormone research in pædiatrics Volume: 73 ISSN: 1663-2826 ISO Abbreviation: Horm Res Paediatr Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-08-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101525157 Medline TA: Horm Res Paediatr Country: Switzerland |
Other Details:
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Languages: eng Pagination: 128-34 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, NSW, Australia. charmait@chw.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Child Female Humans Inflammation Interleukin-10 / blood* Interleukin-6 / blood* Interleukin-8 / blood* Longitudinal Studies Male Obesity / blood*, immunology, physiopathology Puberty Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Interleukin-8; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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