| IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells. | |
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MedLine Citation:
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PMID: 20487626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin 12 (IL 12) p35/p40 is a heterodimeric cytokine which plays a critical role in inflammation, immunity and tissue proliferation, and also plays a relevant function in T helper (Th) cell polarization and Th1 T-cell differentiation. IL-12 family members, IL-12p70, IL-23, IL-27 and IL-35, play an important role in influencing helper T-cell differentiation. EBV-induced gene 3 can be associated with the p35 subunit of IL-12 to form the EBI3/p35 heterodimer, also called IL-35. It has been shown that IL-35 has biological activity and able to expand CD4+CD25+ Treg cells, suppress the proliferation of CD4+CD25- effector cells and inhibit Th17 cell polarization. IL-35 has been shown to be constitutively expressed by regulatory T (Treg) cells CD4(+)CD25(+)Foxp3(+) and suggested to contribute to their suppressive activity. IL-35 is a crucial mediator which provokes CD4+CD25+ T cell proliferation and IL-10 generation, another well-known anti-inflammatory cytokine, along with TGFbeta cytokine. These studies suggest that IL-35, together with other successfully discovered cytokine inhibitors, represents a new potential therapeutic cytokine for chronic inflammation, autoimmunity and other immunological disorders. |
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Authors:
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Maria Luisa Castellani; A Anogeianaki; P Felaco; E Toniato; M A De Lutiis; B Shaik; M Fulcheri; J Vecchiet; S Tetè; V Salini; T C Theoharides; A Caraffa; P Antinolfi; I Frydas; P Conti; C Cuccurullo; C Ciampoli; G Cerulli; D Kempuraj |
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Publication Detail:
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Type: Editorial |
Journal Detail:
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Title: Journal of biological regulators and homeostatic agents Volume: 24 ISSN: 0393-974X ISO Abbreviation: J. Biol. Regul. Homeost. Agents Publication Date: 2010 Apr-Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809253 Medline TA: J Biol Regul Homeost Agents Country: Italy |
Other Details:
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Languages: eng Pagination: 131-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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CD4-Positive T-Lymphocytes
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cytology,
drug effects,
immunology* Cell Differentiation Cell Division / drug effects Cytokines / drug effects, physiology Humans Inflammation / physiopathology Interleukin-12 / pharmacology Interleukins / pharmacology*, physiology* T-Lymphocytes, Helper-Inducer / cytology, physiology T-Lymphocytes, Regulatory / cytology, drug effects, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukins; 0/interleukin-35, human; 187348-17-0/Interleukin-12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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