| IL-33 and IL-33 receptors in host defense and diseases. | |
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MedLine Citation:
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PMID: 20414050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated immune responses such as host defense against nematodes and allergic diseases by inducing production of such Th2-type cytokines as IL-5 and IL-13 by Th2 cells, mast cells, basophils and eosinophils. In addition, IL-33 is involved in the induction of non-Th2-type acute and chronic inflammation as a proinflammatory cytokine, similar to IL-1 and IL-18. In this review, we summarize and discuss the current knowledge regarding the roles of IL-33 and IL-33 receptors in host defense and disease development. |
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Authors:
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Keisuke Oboki; Tatsukuni Ohno; Naoki Kajiwara; Hirohisa Saito; Susumu Nakae |
Publication Detail:
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Type: Journal Article; Review Date: 2010-04-24 |
Journal Detail:
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Title: Allergology international : official journal of the Japanese Society of Allergology Volume: 59 ISSN: 1440-1592 ISO Abbreviation: Allergol Int Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616296 Medline TA: Allergol Int Country: Japan |
Other Details:
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Languages: eng Pagination: 143-60 Citation Subset: IM |
Affiliation:
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Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / genetics, immunology* Host-Pathogen Interactions Humans Hypersensitivity / genetics, immunology* Immunity Infection / genetics, immunology* Inflammation Interleukins / immunology* Mice Polymorphism, Genetic Receptors, Cell Surface / immunology Receptors, Interleukin / immunology Th2 Cells / immunology* Toll-Like Receptors / immunology |
| Chemical | |
Reg. No./Substance:
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0/IL1RL1 protein, human; 0/IL33 protein, human; 0/Il1rl1 protein, mouse; 0/Interleukins; 0/Receptors, Cell Surface; 0/Receptors, Interleukin; 0/Toll-Like Receptors |
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