| IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties. | |
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MedLine Citation:
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PMID: 20655797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IL-28A, IL-28B and IL-29 (also designated type III interferons) constitute a new subfamily within the IL-10-interferon family. They are produced by virtually any nucleated cell type, particularly dendritic cells, following viral infection or activation with bacterial components, and mediate their effects via the IL-28R1/IL-10R2 receptor complex. Although IL-28/IL-29 are closer to the IL-10-related cytokines in terms of gene structure, protein structure, and receptor usage, they display type I interferon-like anti-viral and cytostatic activities. Unlike type I interferons, the target cell populations of IL-28/IL-29 are restricted and mainly include epithelial cells and hepatocytes. These properties suggest that IL-28/IL-29 are potential therapeutic alternatives to type I interferons in terms of viral infections and tumors. This review describes the current knowledge about these cytokines. |
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Authors:
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Katrin Witte; Ellen Witte; Robert Sabat; Kerstin Wolk |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-07-23 |
Journal Detail:
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Title: Cytokine & growth factor reviews Volume: 21 ISSN: 1879-0305 ISO Abbreviation: Cytokine Growth Factor Rev. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612306 Medline TA: Cytokine Growth Factor Rev Country: England |
Other Details:
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Languages: eng Pagination: 237-51 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiviral Agents / metabolism Cytokines / metabolism* Epithelial Cells / metabolism Humans Interferon Type I / physiology* Interferons / genetics Interleukin-10 / metabolism Interleukins / physiology Virus Diseases / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Cytokines; 0/IL28A protein, human; 0/IL28B protein, human; 0/IL29 protein, human; 0/Interferon Type I; 0/Interleukins; 130068-27-8/Interleukin-10; 9008-11-1/Interferons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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