Document Detail

IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction?
MedLine Citation:
PMID:  20861853     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis (AD) is a common skin disease associated with a T(H)2 response and increased levels of T(H)2-associated cytokines and IgE. The mechanisms resulting in skewing the immune response in a T(H)2 direction in AD are not fully elucidated. However, such skewing has recently been associated with IL-25 in a murine model for allergic airway disease. The aim of this study was to investigate whether IL-25 may have a role in AD. We have identified IL-25-producing cells within the dermis of AD patients and propose that these cells are dendritic cells (DCs). This is supported by in vitro experiments that indicate that monocyte-derived DCs are capable of producing IL-25. As null mutations of filaggrin are associated with the development of an impaired skin barrier in AD, we investigated whether IL-25 affects filaggrin synthesis by keratinocytes. Using mRNA analysis, we have shown that IL-25 stimulation does indeed decrease filaggrin synthesis in cultured keratinocytes. These results suggest that IL-25 produced by DCs could have a dual role as both an inducer of the T(H)2 response and as an inhibitor of filaggrin synthesis, thereby directly affecting skin barrier function in AD patients.
Malene Hvid; Christian Vestergaard; Kaare Kemp; Gitte B Christensen; Bent Deleuran; Mette Deleuran
Related Documents :
17090603 - Keratinocyte growth factor protects epidermis and hair follicles from cell death induce...
18439663 - Antimicrobial peptides and the skin immune defense system.
9574553 - Il-10 regulates liver pathology in acute murine schistosomiasis mansoni but is not requ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-23
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  131     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  150-7     Citation Subset:  IM    
Institute of Medical Microbiology and Immunology, Aarhus University, Aarhus C, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cells, Cultured
Dendritic Cells / cytology,  immunology*,  metabolism
Dermatitis, Atopic / immunology*,  metabolism
Flow Cytometry
HLA-DR Antigens / immunology,  metabolism
Interleukin-17 / genetics,  immunology*,  metabolism
Intermediate Filament Proteins / immunology,  metabolism
Keratinocytes / cytology,  immunology*,  metabolism
RNA, Messenger / metabolism
Receptors, Interleukin-17 / immunology,  metabolism
Th2 Cells / immunology,  metabolism
Reg. No./Substance:
0/HLA-DR Antigens; 0/IL25 protein, human; 0/Interleukin-17; 0/Intermediate Filament Proteins; 0/RNA, Messenger; 0/Receptors, Interleukin-17; 0/filaggrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  TP53 Arg72Pro polymorphism and skin cancer risk: a meta-analysis.
Next Document:  Resolved psoriasis lesions retain expression of a subset of disease-related genes.