| Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome. | |
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MedLine Citation:
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PMID: 20729468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2). Interleukin (IL)-25 has been shown to link innate and adaptive immunity by enhancing Th2 cytokine production. We sought to determine the involvement of IL-25 and its receptor IL-17RB in the pathogenesis of CSS. We found increased levels of IL-25 in the serum of active CSS patients (952 ± 697 vs 75 ± 49 pg/mL in inactive patients and 47 ± 6 pg/mL in healthy donors). IL-25 was correlated with disease activity and eosinophil level. Eosinophils were the main source of IL-25, whereas activated CD4(+) memory T cells were the IL-17RB-expressing cells in CSS. IL-25 enhanced the production of IL-4, IL-5, and IL-13 by activated peripheral blood mononuclear cells. IL-25 and IL-17RB were observed within the vasculitic lesions of patients with CSS, and IL-17RB colocalized with T cells. Increased expression of IL-17RB, tumor necrosis factor receptor-associated factor 6, and JunB in vasculitic lesions of CSS underscored the IL-25-mediated activation, whereas up-regulation of GATA3 and IL-10 supported Th2 differentiation. Our findings suggest that eosinophils, through the production of IL-25, exert a critical role in promoting Th2 responses in target tissues of CSS. |
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Authors:
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Benjamin Terrier; Ivan Bièche; Thierry Maisonobe; Ingrid Laurendeau; Michèlle Rosenzwajg; Jean-Emmanuel Kahn; Marie-Claude Diemert; Lucile Musset; Michel Vidaud; Damien Sène; Nathalie Costedoat-Chalumeau; Du Le Thi-Huong; Zahir Amoura; David Klatzmann; Patrice Cacoub; David Saadoun |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-20 |
Journal Detail:
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Title: Blood Volume: 116 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 4523-31 Citation Subset: AIM; IM |
Affiliation:
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Laboratory I3, Immunology, Immunopathology, Immunotherapy, Unité Mixte de Recherche 7211, Centre National de la Recherche Scientifique/Université Pierre et Marie Curie, Institut National de la Santé et de la Recherche Médicale U959, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity* Adolescent Adult Aged CD4-Positive T-Lymphocytes / immunology Churg-Strauss Syndrome / genetics, immunology*, pathology Eosinophils / immunology* Female Gene Expression Profiling Humans Interleukin-17 / blood, genetics, immunology* Male Middle Aged Receptors, Interleukin / genetics, immunology Vasculitis / genetics, immunology, pathology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/IL17RB protein, human; 0/Interleukin-17; 0/Receptors, Interleukin |
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