Document Detail

Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome.
MedLine Citation:
PMID:  20729468     Owner:  NLM     Status:  MEDLINE    
Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2). Interleukin (IL)-25 has been shown to link innate and adaptive immunity by enhancing Th2 cytokine production. We sought to determine the involvement of IL-25 and its receptor IL-17RB in the pathogenesis of CSS. We found increased levels of IL-25 in the serum of active CSS patients (952 ± 697 vs 75 ± 49 pg/mL in inactive patients and 47 ± 6 pg/mL in healthy donors). IL-25 was correlated with disease activity and eosinophil level. Eosinophils were the main source of IL-25, whereas activated CD4(+) memory T cells were the IL-17RB-expressing cells in CSS. IL-25 enhanced the production of IL-4, IL-5, and IL-13 by activated peripheral blood mononuclear cells. IL-25 and IL-17RB were observed within the vasculitic lesions of patients with CSS, and IL-17RB colocalized with T cells. Increased expression of IL-17RB, tumor necrosis factor receptor-associated factor 6, and JunB in vasculitic lesions of CSS underscored the IL-25-mediated activation, whereas up-regulation of GATA3 and IL-10 supported Th2 differentiation. Our findings suggest that eosinophils, through the production of IL-25, exert a critical role in promoting Th2 responses in target tissues of CSS.
Benjamin Terrier; Ivan Bièche; Thierry Maisonobe; Ingrid Laurendeau; Michèlle Rosenzwajg; Jean-Emmanuel Kahn; Marie-Claude Diemert; Lucile Musset; Michel Vidaud; Damien Sène; Nathalie Costedoat-Chalumeau; Du Le Thi-Huong; Zahir Amoura; David Klatzmann; Patrice Cacoub; David Saadoun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-20
Journal Detail:
Title:  Blood     Volume:  116     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4523-31     Citation Subset:  AIM; IM    
Laboratory I3, Immunology, Immunopathology, Immunotherapy, Unité Mixte de Recherche 7211, Centre National de la Recherche Scientifique/Université Pierre et Marie Curie, Institut National de la Santé et de la Recherche Médicale U959, France.
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MeSH Terms
Adaptive Immunity*
CD4-Positive T-Lymphocytes / immunology
Churg-Strauss Syndrome / genetics,  immunology*,  pathology
Eosinophils / immunology*
Gene Expression Profiling
Interleukin-17 / blood,  genetics,  immunology*
Middle Aged
Receptors, Interleukin / genetics,  immunology
Vasculitis / genetics,  immunology,  pathology
Young Adult
Reg. No./Substance:
0/IL17RB protein, human; 0/Interleukin-17; 0/Receptors, Interleukin

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