| IL-23 gene expression in PBMCs of patients with coronary artery disease. | |
MedLine Citation:
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PMID: 23023190 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. Methods: Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR. Results: A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006-0.355). Conclusion: Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis. |
Authors:
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Maryam Khojasteh-Fard; Milad Abolhalaj; Parvin Amiri; Majid Zaki; Zahra Taheri; Mostafa Qorbani; Javad Tavakkoly Bazzaz; Mahsa M Amoli |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-28 |
Journal Detail:
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Title: Disease markers Volume: - ISSN: 1875-8630 ISO Abbreviation: Dis. Markers Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-10-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8604127 Medline TA: Dis Markers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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