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IL-23 gene expression in PBMCs of patients with coronary artery disease.
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MedLine Citation:
PMID:  23023190     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease.
METHODS: Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR.
RESULTS: A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006-0.355).
CONCLUSION: Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis.
Authors:
Maryam Khojasteh-Fard; Milad Abolhalaj; Parvin Amiri; Majid Zaki; Zahra Taheri; Mostafa Qorbani; Javad Tavakkoly Bazzaz; Mahsa M Amoli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  33     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-20     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Artery Disease / genetics,  immunology*,  metabolism
Down-Regulation*
Female
Humans
Interleukin-17 / genetics,  metabolism
Interleukin-23 / genetics*,  metabolism
Lymphocytes / immunology*,  metabolism
Male
Middle Aged
Transcription, Genetic
Transforming Growth Factor beta1 / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Interleukin-17; 0/Interleukin-23; 0/Transforming Growth Factor beta1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2012 Hindawi Publishing Corporation.
Received Day: 21 Month: 9 Year: 2012
Accepted Day: 21 Month: 9 Year: 2012
Print publication date: Year: 2012
Electronic publication date: Day: 5 Month: 12 Year: 2012
Volume: 33 Issue: 6
First Page: 289 Last Page: 293
PubMed Id: 23023190
ID: 3810777
Article Id: 629814
DOI: 10.3233/DMA-2012-00933

IL-23 Gene Expression in PBMCs of Patients with Coronary Artery Disease
Maryam Khojasteh-Fard12
Milad Abolhalaj1
Parvin Amiri1
Majid Zaki1
Zahra Taheri1
Mostafa Qorbani3
Javad Tavakkoly Bazzaz2*
Mahsa M. Amoli1
1Endocrinology and Metabolism Research CenterTehran University of Medical SciencesTehranIran
2Department of Medical GeneticsSchool of MedicineTehran University of Medical SciencesTehranIran
3Department of Epidemiology and BiostatisticsSchool of Public HealthTehran University of Medical SciencesTehranIran
Correspondence: *Javad Tavakkoly Bazzaz: tavakkolybazzazj@tums.ac.ir


Article Categories:
  • Other

Keywords: Cytokine, gene, expression, CAD, IL-23.

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