| IL-23 gene expression in PBMCs of patients with coronary artery disease. | |
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MedLine Citation:
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PMID: 23023190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. METHODS: Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR. RESULTS: A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006-0.355). CONCLUSION: Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis. |
Authors:
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Maryam Khojasteh-Fard; Milad Abolhalaj; Parvin Amiri; Majid Zaki; Zahra Taheri; Mostafa Qorbani; Javad Tavakkoly Bazzaz; Mahsa M Amoli |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Disease markers Volume: 33 ISSN: 1875-8630 ISO Abbreviation: Dis. Markers Publication Date: 2012 |
Date Detail:
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Created Date: 2012-12-11 Completed Date: 2013-05-20 Revised Date: 2013-12-11 |
Medline Journal Info:
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Nlm Unique ID: 8604127 Medline TA: Dis Markers Country: Netherlands |
Other Details:
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Languages: eng Pagination: 289-93 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Disease / genetics, immunology*, metabolism Down-Regulation* Female Humans Interleukin-17 / genetics, metabolism Interleukin-23 / genetics*, metabolism Lymphocytes / immunology*, metabolism Male Middle Aged Transcription, Genetic Transforming Growth Factor beta1 / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-17; 0/Interleukin-23; 0/Transforming Growth Factor beta1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Dis Markers Journal ID (iso-abbrev): Dis. Markers Journal ID (publisher-id): DM ISSN: 0278-0240 ISSN: 1875-8630 Publisher: IOS Press |
Article Information Download PDF  Copyright © 2012 Hindawi Publishing Corporation. Received Day: 21 Month: 9 Year: 2012 Accepted Day: 21 Month: 9 Year: 2012 Print publication date: Year: 2012 Electronic publication date: Day: 5 Month: 12 Year: 2012 Volume: 33 Issue: 6 First Page: 289 Last Page: 293 PubMed Id: 23023190 ID: 3810777 Article Id: 629814 DOI: 10.3233/DMA-2012-00933 |
| IL-23 Gene Expression in PBMCs of Patients with Coronary Artery Disease | |
| Maryam Khojasteh-Fard12 | |
| Milad Abolhalaj1 | |
| Parvin Amiri1 | |
| Majid Zaki1 | |
| Zahra Taheri1 | |
| Mostafa Qorbani3 | |
| Javad Tavakkoly Bazzaz2* | |
| Mahsa M. Amoli1 | |
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1Endocrinology and Metabolism Research CenterTehran University of Medical SciencesTehranIran |
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2Department of Medical GeneticsSchool of MedicineTehran University of Medical SciencesTehranIran |
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3Department of Epidemiology and BiostatisticsSchool of Public HealthTehran University of Medical SciencesTehranIran |
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| Correspondence: *Javad Tavakkoly Bazzaz: tavakkolybazzazj@tums.ac.ir |
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Article Categories:
Keywords: Cytokine, gene, expression, CAD, IL-23. |
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