| IL-22 induces an acute-phase response. | |
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MedLine Citation:
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PMID: 20870942 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IL-22 is made by a unique set of innate and adaptive immune cells, including the recently identified noncytolytic NK, lymphoid tissue-inducer, Th17, and Th22 cells. The direct effects of IL-22 are restricted to nonhematopoietic cells, its receptor expressed on the surface of only epithelial cells and some fibroblasts in various organs, including parenchymal tissue of the gut, lung, skin, and liver. Despite this cellular restriction on IL-22 activity, we demonstrate that IL-22 induces effects on systemic biochemical, cellular, and physiological parameters. By utilizing adenoviral-mediated delivery of IL-22 and systemic administration of IL-22 protein, we observed that IL-22 modulates factors involved in coagulation, including fibrinogen levels and platelet numbers, and cellular constituents of blood, such as neutrophil and RBC counts. Furthermore, we observed that IL-22 induces thymic atrophy, body weight loss, and renal proximal tubule metabolic activity. These cellular and physiological parameters are indicative of a systemic inflammatory state. We observed that IL-22 induces biochemical changes in the liver including induction of fibrinogen, CXCL1, and serum amyloid A that likely contribute to the reported cellular and physiological effects of IL-22. Based on these findings, we propose that downstream of its expression and impact in local tissue inflammation, circulating IL-22 can further induce changes in systemic physiology that is indicative of an acute-phase response. |
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Authors:
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Spencer C Liang; Cheryl Nickerson-Nutter; Debra D Pittman; Yijun Carrier; Debra G Goodwin; Kathleen M Shields; Andre-Jean Lambert; Scott H Schelling; Quintus G Medley; Hak-Ling Ma; Mary Collins; Kyriaki Dunussi-Joannopoulos; Lynette A Fouser |
Publication Detail:
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Type: Journal Article Date: 2010-09-24 |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 185 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-21 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 5531-8 Citation Subset: AIM; IM |
Affiliation:
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Inflammation and Immunology Research Unit, Pfizer Biotherapeutics Research and Development, Cambridge, MA 02140, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Reaction
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immunology*,
physiopathology* Animals Interleukins / immunology* Mice Mice, Inbred C57BL Mice, Knockout |
| Chemical | |
Reg. No./Substance:
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0/Interleukins; 0/interleukin-22 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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