| Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells. | |
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MedLine Citation:
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PMID: 20977918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infection with human immunodeficiency virus (HIV)-1 induces a progressive deterioration of the immune system that ultimately leads to acquired immune deficiency syndrome (AIDS). Murine models indicate that the common γ-chain (γ(c))-sharing cytokine interleukin (IL)-21 and its receptor (IL-21R) play a crucial role in maintaining polyfunctional T cell responses during chronic viral infections. Therefore, we analyzed the ability of this cytokine to modulate the properties of human CD8 T cells in comparison with other γ(c)-sharing cytokines (IL-2, IL-7, and IL-15). CD8 T cells from healthy volunteers were stimulated in vitro via T cell receptor signals to mimic the heightened status of immune activation of HIV-infected patients. The administration of IL-21 upregulated cytotoxic effector function and the expression of the costimulatory molecule CD28. Notably, this outcome was not accompanied by increased cellular proliferation or activation. Moreover, IL-21 promoted antiviral activity while not inducing HIV-1 replication in vitro. Thus, IL-21 may be a favorable molecule for immunotherapy and a suitable vaccine adjuvant in HIV-infected individuals. |
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Authors:
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Anita Parmigiani; Maria F Pallin; Helena Schmidtmayerova; Mathias G Lichtenheld; Savita Pahwa |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-25 |
Journal Detail:
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Title: Human immunology Volume: 72 ISSN: 1879-1166 ISO Abbreviation: Hum. Immunol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-17 Completed Date: 2011-06-29 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 115-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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metabolism,
pharmacology*,
therapeutic use Animals Antigens, CD28 / immunology, metabolism CD8-Positive T-Lymphocytes / immunology*, metabolism Cells, Cultured Granzymes / analysis HIV Infections / drug therapy, immunology, metabolism HIV-1 / drug effects*, immunology, metabolism Humans Immunity, Cellular / drug effects Interleukin-15 / immunology, pharmacology Interleukin-2 / immunology, metabolism Interleukin-7 / immunology, metabolism Interleukins / immunology*, metabolism, pharmacology* Lymphocyte Activation / drug effects, immunology Mice Perforin / analysis Receptors, Antigen, T-Cell / immunology, metabolism Signal Transduction / drug effects, immunology Viral Load Virus Replication / drug effects, immunology |
| Grant Support | |
ID/Acronym/Agency:
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5P30AI073961/AI/NIAID NIH HHS; AI077501/AI/NIAID NIH HHS; R01 AI077501-01/AI/NIAID NIH HHS; R01 AI077501-02/AI/NIAID NIH HHS; R01 AI077501-03/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Antigens, CD28; 0/Interleukin-15; 0/Interleukin-2; 0/Interleukin-7; 0/Interleukins; 0/Receptors, Antigen, T-Cell; 0/interleukin-21; 126465-35-8/Perforin; EC 3.4.21.-/Granzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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