| IL-20: biological functions mediated through two types of receptor complexes. | |
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MedLine Citation:
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PMID: 20864382 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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IL-20 was discovered 10 years ago as a new member of the IL-10 family of cytokines. IL-20 shares the highest amino-acid sequence identity with IL-10, IL-24 and IL-19. IL-20 is secreted by immune cells and activated epithelial cells like keratinocytes. A high expression of the corresponding IL-20 receptor chains is detected on epithelial cells. In terms of function, IL-20 might therefore mediate a crosstalk between epithelial cells and tissue-infiltrating immune cells under inflammatory conditions. Transgenic and knockout mouse models for some cytokines and receptors of the IL-10-type cytokines have provided new insights into the biology of this family. This review will focus on the biological functions of IL-20 and its receptors within the IL-10 cytokine network. |
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Authors:
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Ursula Maria Wegenka |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-16 |
Journal Detail:
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Title: Cytokine & growth factor reviews Volume: 21 ISSN: 1879-0305 ISO Abbreviation: Cytokine Growth Factor Rev. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612306 Medline TA: Cytokine Growth Factor Rev Country: England |
Other Details:
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Languages: eng Pagination: 353-63 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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University Medical Center, Center of Internal Medicine, Department of Internal Medicine I, Robert-Koch-Strasse 8, D-89081 Ulm, Germany. ursula.wegenka@uni-ulm.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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