| IL-2: a two-faced master regulator of autoimmunity. | |
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MedLine Citation:
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PMID: 21282039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD4(+) T-cell (Th) cytokines provide important regulatory and effector functions of T-cells. Among them, IL-2 plays a unique role. IL-2 is required for the generation and maintenance of regulatory T-cells (Treg) to provide lifelong protection from autoimmune disease. Whether IL-2 is also required for autoimmune disease development is less clear as Il2(-/)(-) mice themselves spontaneously develop multi-organ inflammation (MOI). In this communication, we discuss evidence that support the thesis that IL-2 is required for the development of autoimmune response, although some aspects of autoimmune response are not regulated by IL-2. Potential IL-2-dependent mechanisms operating at specific stages of the inflammation process are presented. The interplays among Treg, IL-2, autoimmune response and adaptive immunity are discussed. Overall, available information indicates that IL-2 is a two-faced master regulator of autoimmunity: one to prevent autoimmunity while the other promotes autoimmune response. The latter is an unfortunate consequence of IL-2 function that is used to promote the adaptive immune response against foreign antigens and pathogens. |
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Authors:
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Rahul Sharma; Shu Man Fu; Shyr-Te Ju |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-02-01 |
Journal Detail:
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Title: Journal of autoimmunity Volume: 36 ISSN: 1095-9157 ISO Abbreviation: J. Autoimmun. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-28 Completed Date: 2011-07-22 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 8812164 Medline TA: J Autoimmun Country: England |
Other Details:
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Languages: eng Pagination: 91-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, University of Virginia, VA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Presenting Cells / immunology, metabolism Antigens / immunology Autoimmunity / immunology* Humans Inflammation / immunology Interleukin-2 / deficiency, genetics, immunology* Mice Mice, Knockout Models, Immunological T-Lymphocytes / immunology*, metabolism T-Lymphocytes, Regulatory / immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AR-047988/AR/NIAMS NIH HHS; AR-049449/AR/NIAMS NIH HHS; AR-051203/AR/NIAMS NIH HHS; DE-01759/DE/NIDCR NIH HHS; R01 AR051203-05/AR/NIAMS NIH HHS; R01 DE017570-05/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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