| Multiple antimelanoma potential of dry olive leaf extract. | |
| | |
MedLine Citation:
|
PMID: 20568104 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Various constituents of the olive tree (Olea europaea) have been traditionally used in the treatment of infection, inflammation, prevention of chronic diseases, cardiovascular disorders and cancer. The anticancer potential of dry olive leaf extract (DOLE) represents the net effect of multilevel interactions between different biologically active compounds from the extract, cancer cells and conventional therapy. In this context, it was of primary interest to evaluate the influence of DOLE on progression of the highly malignant, immuno- and chemoresistant type of skin cancer-melanoma. DOLE significantly inhibited proliferation and subsequently restricted clonogenicity of the B16 mouse melanoma cell line in vitro. Moreover, late phase tumor treatment with DOLE significantly reduced tumor volume in a syngeneic strain of mice. DOLE-treated B16 cells were blocked in the G(0) /G(1) phase of the cell cycle, underwent early apoptosis and died by late necrosis. At the molecular level, the dying process started as caspase dependent, but finalized as caspase independent. In concordance, overexpression of antiapoptotic members of the Bcl-2 family, Bcl-2 and Bcl-XL, and diminished expression of their natural antagonists, Bim and p53, were observed. Despite molecular suppression of the proapoptotic process, DOLE successfully promoted cell death mainly through disruption of cell membrane integrity and late caspase-independent fragmentation of genetic material. Taken together, the results of this study indicate that DOLE possesses strong antimelanoma potential. When DOLE was applied in combination with different chemotherapeutics, various outcomes, including synergy and antagonism, were observed. This requires caution in the use of the extract as a supplementary antitumor therapeutic. |
| | |
Authors:
|
Sanja A Mijatovic; Gordana S Timotijevic; Djordje M Miljkovic; Julijana M Radovic; Danijela D Maksimovic-Ivanic; Dragana P Dekanski; Stanislava D Stosic-Grujicic |
Related Documents
:
|
10858324 - Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon tr... 20940624 - P-glycoprotein transporter expression on a549 respiratory epithelial cells is positivel... 8638674 - Xenobiotic transport differences in mouse mesangial cell clones expressing mdr1 and mdr3. 1363514 - Increase of vinblastine accumulation by inhibitors of calmodulin-dependent cell functio... 11472834 - Top-der- and dpp-dependent requirements for the drosophila fos/kayak gene in follicular... 18565804 - Cell mechanics of alveolar epithelial cells (aecs) and macrophages (ams). |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of cancer. Journal international du cancer Volume: 128 ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 1955-65 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 UICC. |
Affiliation:
|
Department of Immunology, Institute for Biological Research "Sinisa Stankovic," Belgrade University, Belgrade, Serbia. sanjamama@yahoo.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Trends in cervical cancer incidence and mortality in the Baltic countries, Bulgaria and Romania.
Next Document: IL-2-granzyme A chimeric protein overcomes multidrug resistance (MDR) through a caspase 3-independen...