| The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity. | |
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MedLine Citation:
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PMID: 20625413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE. Decreased IL-2 production in SLE patients leads to many immune defects such as decreased T(reg) production, decreased activation-induced cell death (AICD), and decreased cytotoxicity. IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease. |
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Authors:
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Linda A Lieberman; George C Tsokos |
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Publication Detail:
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Type: Journal Article Date: 2010-06-06 |
Journal Detail:
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Title: Journal of biomedicine & biotechnology Volume: 2010 ISSN: 1110-7251 ISO Abbreviation: J. Biomed. Biotechnol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-13 Completed Date: 2010-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135740 Medline TA: J Biomed Biotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 740619 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, CLS 937, Boston, MA 02115, USA. llieber1@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Death Disease Models, Animal Humans Immunity / immunology* Interleukin-2 / biosynthesis, deficiency, immunology* Lupus Erythematosus, Systemic / immunology* Lymphocyte Activation / immunology Mice Receptors, Interleukin-2 / deficiency T-Lymphocytes / cytology, immunology T-Lymphocytes, Regulatory / cytology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2; 0/Receptors, Interleukin-2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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