Document Detail


IL-1β receptor antagonist reduces inflammation in hemodialysis patients.
MedLine Citation:
PMID:  21310819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic inflammation is highly prevalent in maintenance hemodialysis (MHD) patients and associates with increased mortality. IL-1β, a pro-inflammatory cytokine, is elevated in MHD patients. A balance between IL-1β and its naturally occurring antagonist may determine the inflammatory response and its consequences in this population. We performed a pilot randomized placebo-controlled trial to evaluate the efficacy of the administration of recombinant human IL-1 receptor antagonist (IL-1ra) on biomarkers of inflammation and nutrition in MHD patients with three consecutive high sensitivity C-reactive protein (hsCRP) measurements >5 mg/L. We randomly assigned 22 patients to placebo or IL-1ra (1:1) for 4 weeks; 14 completed the trial. Patients in the IL-1ra arm had a 53% reduction in mean hsCRP compared with 1% in the placebo arm (P = 0.008), a 40% reduction in mean IL-6 levels compared with a 20% increase in the placebo arm (P = 0.03), and a 23% increase in mean prealbumin compared with 6% in the placebo arm (P = NS). In conclusion, the administration of IL-1ra in MHD patients can lower biomarkers of inflammation. Whether IL-1ra administration improves survival in this population requires additional long-term studies.
Authors:
Adriana M Hung; Charles D Ellis; Ayumi Shintani; Cindy Booker; T Alp Ikizler
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-02-10
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  22     ISSN:  1533-3450     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-04     Completed Date:  2011-06-16     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue South & Garland, Nashville, TN 37232-2372, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
C-Reactive Protein / metabolism
Chronic Disease
Double-Blind Method
Female
Humans
Inflammation / blood,  etiology,  prevention & control*
Interleukin 1 Receptor Antagonist Protein / therapeutic use*
Interleukin-1beta / blood
Interleukin-6 / blood
Kidney Diseases / blood,  complications,  therapy*
Male
Middle Aged
Pilot Projects
Receptors, Interleukin-1 / antagonists & inhibitors*
Renal Dialysis*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
1UL-1RR024975/RR/NCRR NIH HHS; K24 DK 062849/DK/NIDDK NIH HHS; R21 DK077373/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1beta; 0/Interleukin-6; 0/Receptors, Interleukin-1; 9007-41-4/C-Reactive Protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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