Document Detail

IL-18 level correlates with development of sepsis in surgical patients.
MedLine Citation:
PMID:  17691022     Owner:  NLM     Status:  MEDLINE    
Interleukin 18 may play an important role in sepsis. We measured circulating IL-18 levels in 47 patients with surgical wounds, 27 of them had clinical and laboratory evidences of sepsis. The patients had significantly higher IL-18 levels than healthy control (p1 = 0.001), patients with local infection (p4 = 0.001) and patients with clean surgical wound (p5 = 0.001) both at admission and after 48 hours. Serial observations revealed that in all patients, IL-18 levels increased significantly especially in patients with sepsis after 48 h (p = 0.007). IL-18 levels appeared to correlate significantly with leucocytes counts (p = 0.001) and with C-RP (p = 0.007). These results suggest that IL-18 levels are increased in patients with sepsis and correlate with CRP and leukocyte counts suggesting that IL-18 may play a role in sepsis. We suggest that IL-18 could be used as a collaborative evidence of surgical sepsis.
Maysaa El-Sayed Zaki; Mohammed Yousef Elgendy; Noha Badr El-Deen El-Mashad; Mohammed Ebrahim Farahat
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunological investigations     Volume:  36     ISSN:  0882-0139     ISO Abbreviation:  Immunol. Invest.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504629     Medline TA:  Immunol Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-11     Citation Subset:  IM    
Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
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MeSH Terms
C-Reactive Protein / analysis*
Interleukin-18 / blood,  immunology*
Middle Aged
Sepsis / blood,  immunology*,  microbiology
Surgical Wound Infection / immunology*,  metabolism,  microbiology,  surgery
Reg. No./Substance:
0/Interleukin-18; 9007-41-4/C-Reactive Protein

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