| IL-17A is involved in bacteria-related acute pleural inflammation. | |
MedLine Citation:
|
PMID: 23237544 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVE: The role of pro-inflammatory Interleukin-17A (IL-17A), in pleural diseases is unknown. We sought to investigate IL-17A expression and its clinical implications in patients with pleural effusion (PE) and IL-17A involvement in the pathobiology of pleural inflammation elicited by bacterial products. METHODS: Pleural and blood IL-17A content was examined in 84 patients with PEs of different etiologies and the diagnostic value of pleural IL17A was explored in 92 patients with neutrophil-predominant PEs. IL-17A contribution in pleural inflammation was evaluated in mice injected intrapleurally with either IL-17A or bacterial products with or without IL-17A-neutralizing antibodies. RESULTS: IL-17A was up-regulated in the pleural space of patients with parapneumonic PEs. It was detected in a minority of patients with tuberculus PEs and very uncommonly in patients with malignant or other pleural exudates. Pleural fluid IL-17A levels were correlated with markers of acute pleural inflammation as well as vascular endothelial growth factor and IL-8 levels. Among patients with neutrophil-predominant PEs, PF IL-17A was detected only in those with parapneumonic PEs, though the sensitivity of the test was low (<50%). Intrapleural injection of IL-17A elicited a neutrophil-predominant inflammatory response in mice and IL-17A neutralization partially blocked pleural neutrophilia induced by intrapleural administration of bacterial products. CONCLUSIONS: IL-17A is involved in pleural inflammation related to bacterial infection. Moreover, pleural IL-17A levels may be helpful in uncovering an infectious etiology among patients with neutrophil-predominant PEs. |
Authors:
|
Androniki Kolllintza; Sofia Magouta; Ioannis Psallidas; Charalampos Moschos; Magdalini Stratiki; Aureli Esquerda; José M Porcel; Ioannis Kalomenidis |
Related Documents
:
|
7435264 - Effect of metoprolol on qtc intervals after acute myocardial infarction. 6540514 - Prognosis in hypertrophic cardiomyopathy. 6833194 - Electrocardiographic effects of tranylcypromine vs. amitriptyline. 2017974 - Electrophysiologic effects and clinical hazards of carbamazepine treatment for neurolog... 18695164 - Generic substitution in the treatment of epilepsy: case evidence of breakthrough seizures. 12694094 - Intra-esophageal ph probe movement during eating and talking. a videoradiographic study. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-12 |
Journal Detail:
|
Title: Respirology (Carlton, Vic.) Volume: - ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9616368 Medline TA: Respirology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology. |
Affiliation:
|
Applied Biomedical Research & Training Center "Marianthi Simou",, Department of Critical Care & Pulmonary Services, General Hospital "Evangelismos", School of Medicine, National and Kapodistrian University of Athens, 3 Ploutarhou street, 10675, Athens, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A 3D porous media liver lobule model: the importance of vascular septa and anisotropic permeability ...
Next Document: Ionoluminescence in the helium ion microscope.