Document Detail


IL-17A is involved in bacteria-related acute pleural inflammation.
MedLine Citation:
PMID:  23237544     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: The role of pro-inflammatory Interleukin-17A (IL-17A), in pleural diseases is unknown. We sought to investigate IL-17A expression and its clinical implications in patients with pleural effusion (PE) and IL-17A involvement in the pathobiology of pleural inflammation elicited by bacterial products. METHODS: Pleural and blood IL-17A content was examined in 84 patients with PEs of different etiologies and the diagnostic value of pleural IL17A was explored in 92 patients with neutrophil-predominant PEs. IL-17A contribution in pleural inflammation was evaluated in mice injected intrapleurally with either IL-17A or bacterial products with or without IL-17A-neutralizing antibodies. RESULTS: IL-17A was up-regulated in the pleural space of patients with parapneumonic PEs. It was detected in a minority of patients with tuberculus PEs and very uncommonly in patients with malignant or other pleural exudates. Pleural fluid IL-17A levels were correlated with markers of acute pleural inflammation as well as vascular endothelial growth factor and IL-8 levels. Among patients with neutrophil-predominant PEs, PF IL-17A was detected only in those with parapneumonic PEs, though the sensitivity of the test was low (<50%). Intrapleural injection of IL-17A elicited a neutrophil-predominant inflammatory response in mice and IL-17A neutralization partially blocked pleural neutrophilia induced by intrapleural administration of bacterial products. CONCLUSIONS: IL-17A is involved in pleural inflammation related to bacterial infection. Moreover, pleural IL-17A levels may be helpful in uncovering an infectious etiology among patients with neutrophil-predominant PEs.
Authors:
Androniki Kolllintza; Sofia Magouta; Ioannis Psallidas; Charalampos Moschos; Magdalini Stratiki; Aureli Esquerda; José M Porcel; Ioannis Kalomenidis
Related Documents :
7435264 - Effect of metoprolol on qtc intervals after acute myocardial infarction.
6540514 - Prognosis in hypertrophic cardiomyopathy.
6833194 - Electrocardiographic effects of tranylcypromine vs. amitriptyline.
2017974 - Electrophysiologic effects and clinical hazards of carbamazepine treatment for neurolog...
18695164 - Generic substitution in the treatment of epilepsy: case evidence of breakthrough seizures.
12694094 - Intra-esophageal ph probe movement during eating and talking. a videoradiographic study.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-12
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Affiliation:
Applied Biomedical Research & Training Center "Marianthi Simou",, Department of Critical Care & Pulmonary Services, General Hospital "Evangelismos", School of Medicine, National and Kapodistrian University of Athens, 3 Ploutarhou street, 10675, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A 3D porous media liver lobule model: the importance of vascular septa and anisotropic permeability ...
Next Document:  Ionoluminescence in the helium ion microscope.